溶酶体相关细胞器:生物发生与功能

Lysosome Related Organelles: Biogenesis and Functions

溶酶体相关细胞器是真核动物细胞中功能特异的细胞器,其装配、成熟及运输过程需要借助内体–溶酶体运输途经。该文总结了具有代表性的四种溶酶体相关细胞器(黑素小体、血小板致密颗粒、大致密核心颗粒及Weibel-Palade小体)的结构、功能、生物发生的分子细胞机制,为更深入了解溶酶体相关细胞器的生理和病理意义提供参考。

LROs(lysosome-related organelles)are a class of organelles with specific functions in eukaryotic cells,and their assembly,maturation,and trafficking processes take advantage of the endo-lysosomal pathways.This review summarizes the molecular cellular mechanisms of the structure,function,and biogenesis of four representative LROs(melanosomes,platelet dense granules,large dense-core vesicles,and Weibel-Palade bodies),providing some cues for a better understanding of the pathophysiological roles of LROs.