抗癫痫发作药物联合使用中国专家共识

Chinese consensus for the anti-seizure medications polytherapy

癫痫是中枢神经系统常见的慢性疾病之一,给予抗癫痫发作药物(ASMs)是其最重要的治疗手段,初始单药未达到癫痫缓解的治疗目标时,可选择更换单药或联合添加治疗。中国目前有超过20种上市的ASMs,对于何时启动联合治疗、联合用药的方案、多药治疗的注意事项等问题常给临床决策带来困扰。为此,中华医学会神经病学分会脑电图与癫痫学组组织相关专家,讨论并撰写本共识,旨在为我国癫痫疾病的药物联合治疗提供更加实用、规范的治疗方案及用药指导。

Epilepsy is one of the common chronic diseases of the central nervous system,and the therapy of anti-seizure medications(ASMs)is the most important therapy method for epilepsy.If the treatment goal of seizure-free is not reached after the initial monotherapy,another ASMs should be selected as substitution or combination therapy.At present,there are more than 20 kinds of ASMs licensed for use in China.A series of problems,such as when to start the ASMs polytherapy,the choice of polytherapy schedules,and the precautions for polytherapy,often cause problems for clinicians to make decisions.Therefore,experts from the Chinese Society of Electroencephalography and Epilepsy discussed and wrote"Chinese consensus for the anti-seizure medications polytherapy",aimed to provide clinicians with practical,standardized treatment for the patients with ASMs polytherapy in China.