小脑非侵入性刺激对认知功能调控的研究进展

Research progress in the regulation of cognitive function by cerebellar non-invasive stimulation

认知功能下降是神经系统变性疾病的主要临床症状之一,目前尚无特效药物治疗措施,严重影响患者生活质量与康复进程。以经颅磁刺激和经颅电刺激为代表的非侵入性脑刺激技术具有无创性、无痛性、易操作性等优点,已在临床中用于认知障碍的治疗,尤其在改善记忆力、注意力、定向力和语言能力等认知功能方面取得了较好的效果。近年来,大脑-小脑环路参与学习与记忆的相关研究备受关注,小脑已成为非侵入性脑刺激技术探索的新靶点。但小脑非侵入性脑刺激与认知功能调控的相关性尚无明确定论。文中就小脑参与认知功能调控的解剖和功能基础以及小脑非侵入性刺激对认知功能的调控进行综述,以期为小脑非侵入性脑刺激干预认知损害疾病提供依据。

Cognitive decline is one of the main clinical symptoms of neurodegenerative diseases.There is no specific drug treatment,which seriously affects the quality of life and rehabilitation process of these patients.Non-invasive brain stimulation(NIBS)technology such as transcranial magnetic stimulation and transcranial electrical stimulation known as its advantages of non-invasive,painless,and easy to operate,has been used in clinical treatment of cognitive disorders.In particular,it has a good effect on improving cognitive functions such as memory,attention,orientation and language ability.In recent years,the study of cerebellar involvement in learning and memory through brain-cerebellar circuit has attracted much attention,and cerebellum has become a new target for NIBS technology exploration.However,the correlation between cerebellar NIBS and cognitive function regulation is still unclear.This paper aims to provide the evidences of the anatomic and functional basis of cerebellar involvement in cognitive function regulation and cerebellar non-invasive stimulation on cognitive function regulation.