不同手术方式对术后鼻窦局部激素应用的影响

Effects of different surgical methods on the application of topical hormones in the sinus after operation

慢性鼻窦炎(chronic rhinosinusitis,CRS)是耳鼻咽喉科常见的慢性炎性疾病,其中以嗜酸粒细胞型CRS伴鼻息肉为代表的难治性CRS(difficult-to-treat chronic rhinosinusitis,DTCRS)预后较差,严重影响着人们的身心健康。DTCRS的治疗手段多样,包括药物治疗、生物治疗及手术等。近年来,内镜下鼻窦手术和术后鼻用激素的局部给药作为其治疗手段之一,已取得较好成效。本文针对手术这一治疗手段,以内镜下鼻窦手术方式对DTCRS患者术后鼻用糖皮质激素可分布范围的影响,进而对术后疗效的影响为中心,回顾了国内外相关文献并加以综述,以期为DTCRS的临床治疗提供参考。

Chronic rhinosinusitis(CRS) is a common chronic inflammatory disease in otorhinolaryngology,in which eosinophilic chronic rhinosinusitis with nasal polyps represents the difficult-to-treat chronic rhinosinusitis(DTCRS) with poor prognosis.DTCRS has a poor prognosis,which seriously affects people's physical and mental health,and is treated with various means,including medication,biotherapy and surgery.In recent years,endoscopic sinus surgery and postoperative local administration of nasal hormones as one of its treatment methods have achieved good results.In this paper,we review the relevant literature at home and abroad and give an overview for the treatment means of surgery,focusing on the effect of endoscopic sinus surgery on the distributable range of postoperative nasal glucocorticosteroids in patients with DTCRS,and then on the postoperative efficacy of the treatment,with a view to providing a reference for the clinical treatment of DTCRS.