补体相关性肾病诊断和治疗专家共识

Consensus on diagnosis and treatment of complement-mediated kidney diseases

随着补体系统在各类肾脏疾病中的作用机制逐渐阐明,针对补体活化不同环节的药物相继出现,部分已应用于临床。但补体靶向治疗仍存在诸多问题。北京大学医学系补体相关性肾病诊断和治疗专家共识协作组在国内外肾脏疾病指南/共识的基础上,结合最新证据制定了本共识,简述了补体相关性肾病的发病机制、诊断思路、补体靶向治疗与特殊致病微生物的疫苗免疫等方面的最新证据和建议,为补体相关性肾病的诊断和治疗提供参考。

In recent years,the role of complement in various kidney diseases has been gradually elucidated,and drugs targeting complement system have emerged successively,and some of them have been applied in clinical practice.However,there are some problems with complement-targeted therapy.This consensus was initiated by a collaborative group of experts in the diagnosis and treatment of complement-mediated kidney diseases from the medical department of Peking University.Their efforts drew upon domestic and international guidelines/consensuses,as well as the latest literature.The evidence and suggestions on the pathogenesis,diagnosis,complement targeted therapy and vaccine immunization of special pathogenic microorganisms of complement-mediated kidney diseases are briefly described,which aims to provide a reference for the diagnosis and treatment of complement-mediated kidney diseases.