外用氨甲环酸联合调Q激光治疗痤疮后色素沉着患者的效果

Effects of topical Tranexamic acid combined with Q-switched laser in treatment of patients with pigmentation after acne

目的:探讨外用氨甲环酸联合调Q激光治疗痤疮后色素沉着患者的效果。方法:回顾性分析2021年8月至2023年1月该院收治的90例痤疮后色素沉着患者的临床资料,按照治疗方式不同将其分为对照组和研究组各45例。对照组采用调Q激光治疗,研究组在对照组基础上联合1%氨甲环酸溶液贴敷治疗。比较两组临床疗效、治疗前后皮肤色斑情况[黑素指数(MI)、红斑指数(EI)]、皮肤生理功能指标(皮肤角质层含水量、经表皮失水率和pH值)及不良反应发生率。结果:研究组治疗总有效率为88.89%(40/45),高于对照组的71.11%(32/45),差异有统计学意义(P<0.05);治疗后,研究组MI、EI评分及经表皮失水率均低于对照组,患处皮肤角质层含水量、pH值均高于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为6.67%(3/45),低于对照组的22.22%(10/45),差异有统计学意义(P<0.05)。结论:外用氨甲环酸联合调Q激光治疗痤疮后色素沉着患者效果显著,能够减轻色素沉着,改善皮肤生理功能,降低不良反应发生率,效果优于单用调Q激光治疗。

Objective:To investigate effects of topical Tranexamic acid combined with Q-switched laser in treatment of patients with pigmentation after acne.Methods:The clinical data of 90 patients with pigmentation after acne admitted to this hospital from August 2021 to January 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and study group,45 cases in each group.The control group was treated with Q-switched laser,while the study group was treated with 1%Tranexamic acid solution patching on the basis of that of the control group.The clinical efficacy,the skin pigmentation before and after the treatment[melanin index(MI),erythema index(EI)],the skin physiological function indexes(skin stratum corneum water content,transepidermal water loss rate and pH value)levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 88.89%(40/45),which was higher than 71.11%(32/45)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the MI and EI scores and the transepidermal water loss rate of the study group were lower than those of the control group,the water content and pH value of the stratum corneum of the affected skin were higher than those of the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the study group was 6.67%(3/45),which was lower than 22.22%(10/45)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Topical Tranexamic acid combined with Q-switched laser is effective in the treatment of the patients with pigmentation after acne,which can reduce the pigmentation,improve the skin physiological function and reduce the incidence of adverse reactions.Moreover,it is superior to single Q-switched laser treatment.