维生素E联合黄体酮注射液治疗先兆流产患者的效果

Clinical effects of Vitamin E combined with Progesterone injection in treatment of patients with threatened abortion

目的:分析维生素E联合黄体酮注射液治疗先兆流产患者的效果。方法:回顾性分析2021年3月至2022年3月该院收治的70例先兆流产患者的临床资料,依据治疗方法不同将其分为观察组和对照组,每组35例,对照组给予黄体酮注射液治疗,观察组给予维生素E联合黄体酮注射液治疗。比较两组临床疗效和保胎成功率,治疗前后子宫胎盘灌注状态及性激素、辅助性T细胞(Th)1/Th2细胞因子和血清学指标水平。结果:治疗后,观察组治疗总有效率和保胎成功率均高于对照组,人绒毛膜促性腺激素、孕酮、雌二醇、白细胞介素(IL)-4水平高于对照组,血流搏动指数、血流阻力指数及血清γ干扰素、IL-2水平均低于对照组,差异有统计学意义(P<0.05);观察组血清可溶性人类白细胞抗原-G水平高于对照组,血清高迁移率族蛋白B1和核苷酸结合寡聚化结构域样受体3水平均低于对照组,差异有统计学意义(P<0.05)。结论:维生素E联合黄体酮注射液治疗先兆流产患者效果较佳,可改善子宫胎盘灌注状态,调节性激素水平和Th1/Th2细胞因子状态,利于改善妊娠结局,效果优于单纯黄体酮注射液治疗。

Objective:To analyze clinical effects of Vitamin E combined with Progesterone injection in treatment of patients with threatened abortion.Methods:The clinical data of 70 patients with threatened abortion admitted to the hospital from March 2021 to March 2022 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,35 cases in each group.The control group was treated with Progesterone injection,while the observation group was treated with Vitamin E combined with Progesterone injection.The clinical efficacy,the success rate of tocolysis,the uterine and placental perf usion status and levels of sex hormones,the levels of Th1/Th2 cytokines and serological indexes were compared between the two groups before and after the treatment.Results:After the treatment,the total effective rate and the success rate of tocolysis in the observation group were higher than those in the control group;the levels of human chorionic gonadotropin,progesterone,estradiol and interleukin(IL)-4 in the observation group were higher than those in the control group;the blood flow pulsation index,blood flow resistance index and serum levels of interferon-γand IL-2 in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).The serum soluble human leukocyte antigen-G level in the observation group was higher than that in the control group,the serum high mobility group protein B1 and nucleotide-binding oligomerization domain-like receptor 3 levels were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Vitamin E combined with Progesterone injection is effective in the treatment of the patients with threatened abortion.It can improve the uterine and placental perfusion status,regulate the sex hormone levels and Th1/Th2 cytokine status,and improve the pregnancy outcome.Moreover,it is superior to single Progesterone injection.