丁苯酞联合神经节苷脂治疗急性脑梗死的临床疗效及对患者神经功能的影响

The Clinical Efficacy of the Combination of Butylphthalide and Gangliosides in the Treatment of Acute Cerebral Infarction and its Impact on the Neurological Function of Patients

【目的】探讨丁苯酞联合神经节苷脂治疗急性脑梗死(ACI)的临床疗效及其对患者神经功能的影响。【方法】选取2021年3月至2022年12月本院收治的98例ACI患者,采用随机数字表法将其分为对照组和观察组,每组49例。对照组采用神经节苷脂治疗,观察组采用丁苯酞联合神经节苷脂治疗。比较两组患者临床总有效率、相关评分[Barthel指数评定量表(BI)、脑卒中专用生活质量量表(SS-QOL)、美国国立卫生院卒中量表(NIHSS)]、神经功能指标[神经元特异性烯醇化酶(NSE)、中枢神经特异蛋白(S100β)、髓磷脂碱性蛋白(MBP)]水平、血流动力学指标[血全素黏度(WBV)、血浆黏度(FIB)、红细胞压积(HCT)、凝血因子(PV)]及血清血管内皮生长因子(VEGF)、氧化三甲胺(TMAO)、血栓素A2(TXA2)、内皮素1(ET-1)水平。【结果】观察组临床总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分低于治疗前,BI评分、SS-QOL评分高于治疗前,且观察组与对照组比较,差异有统计学意义(P<0.05);两组NSE、S100β及MBP水平均低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05);两组患者HCT、WBV、FIB及PV水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组血清VEGF水平高于治疗前,ET-1、TMAO、TXA2水平低于治疗前,且观察组与对照组比较,差异有统计学意义(P<0.05)。【结论】丁苯酞联合神经节苷脂治疗ACI疗效较好,促进神经功能恢复,提高患者生活质量。

【Objective】To explore the clinical efficacy of the combination of butylphthalide and gangliosides in the treatment of acute cerebral infarction(ACI)and its impact on the neurological function of patients.【Methods】A total of 98 ACI patients admitted to our hospital from March 2021 to December 2022 were selected and randomly divided into a control group and an observation group using a random number table method,with 49 cases in each group.The control group received treatment with gangliosides,while the observation group received treatment with a combination of butylphthalide and gangliosides.We compared two groups of clinical total effective rates,related scores[Barthel Index Rating Scale(BI),Stroke Specific Quality of Life Scale(SS-QOL),National Institutes of Health Stroke Scale(NIHSS)],neurological function indicators[Neuron Specific Enolase(NSE),Central Nervous System Specific Protein(S100β),Myelin Basic Protein(MBP)]levels,hemodynamic indicators(WBV,FIB)Blood cell hematocrit(HCT),coagulation factor(PV),and serum levels of vascular endothelial growth factor(VEGF),trimethylamine oxide(TMAO),thromboxane A2(TXA2),and endothelin 1(ET-1).【Results】The total clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the NIHSS score of the two groups of patients was lower than before treatment,while the BI score and SS-QOL score were higher than before treatment.The difference between the observation group and the control group was statistically significant(P<0.05);The levels of NSE,S100β,and MBP in both groups were lower than before treatment,while the observation group was lower than the control group,and the difference was statistically significant(P<0.05);The levels of HCT,WBV,FIB,and PV in the two groups of patients were lower than before treatment,and the observation group was lower than the control group,with statistical significance(P<0.05);The serum VEGF levels of the two groups were higher than before treatment,while the levels of ET-1,TMAO,and TXA2 were lower than before treatment.The difference between the observation group and the control group was statistically significant(P<0.05).【Conclusion】The combination of butylphthalide and gangliosides has a good therapeutic effect on ACI,and improve the quality of life of patients.