不同部位注射NGF治疗突发性耳聋对患者听力及症状的影响

The Effect of Injecting NGF into Different Parts of the Body on the Hearing and Symptoms of Patients with Sudden Deafness

【目的】探讨不同部位注射鼠神经生长因子(NGF)治疗突发性耳聋对患者听力及症状的影响。【方法】选取2019年10月至2022年10月韩城市人民医院收治的70例突发性耳聋患者,按照随机数字表法分为观察组和对照组,每组35例。对照组采用臀部注射NGF治疗,观察组采用耳后乳突骨膜下注射NGF治疗。比较两组患者临床疗效、不良反应发生率、临床症状(包括耳鸣、耳闷、眩晕)消失时间及治疗前后听阈值(包括骨传导、空气传导听阈值)。【结果】观察组临床疗效总有效率为94.29%,显著高于对照组的74.29%,差异有统计学意义(P<0.05)。观察组耳鸣、耳闷、眩晕消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者骨传导、空气传导听阈值均低于同组治疗前,差异有统计学意义(P<0.05);且观察组治疗后骨传导、空气传导听阈值均低于对照组治疗后,差异有统计学意义(P<0.05)。两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】与臀部注射NGF相比,耳后乳突骨膜下注射NGF治疗突发性耳聋临床疗效更好,患者临床症状改善更明显,促进患者听力恢复,且安全性较高。

【Objective】To explore the effects of injecting rat nerve growth factor(NGF)into different parts of the body on the hearing and symptoms of patients with sudden deafness.【Methods】A total of 70 patients with sudden deafness admitted to the Hancheng People's Hospital from October 2019 to October 2022 were randomly divided into an observation group and a control group,with 35 cases in each group,using a random number table method.The control group received NGF injection into the buttocks,while the observation group received NGF injection under the periosteum of the mastoid process behind the ear.We compared the clinical efficacy,incidence of adverse reactions,disappearance time of clinical symptoms(including tinnitus,ear tightness,and dizziness),and hearing threshold values(including bone conduction and air conduction hearing thresholds)before and after treatment between two groups of patients.【Results】The total effective rate of clinical efficacy in the observation group was 94.29%,significantly higher than the control group's 74.29%,and the difference was statistically significant(P<0.05).The disappearance time of tinnitus,ear tightness,and dizziness in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the bone conduction and air conduction hearing thresholds of the two groups of patients were lower than before treatment,and the difference was statistically significant(P<0.05);After treatment,the bone conduction and air conduction hearing thresholds in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups of patients(P>0.05).【Conclusion】Compared with the injection of NGF into the buttocks,the injection of NGF into the subperiosteal area behind the ear and mastoid process has better clinical efficacy in the treatment of sudden deafness,with more significant improvement in clinical symptoms,promotion of hearing recovery,and higher safety.