含锶脱敏牙膏对牙本质过敏症脱敏作用的Meta分析

Meta Analysis of the Desensitization Effect of Strontium Containing Desensitizing Toothpaste on Dentin Hypersensitivity

目的:采用Meta分析评价含锶脱敏牙膏对牙本质过敏症(DH)的治疗效果,为临床治疗提供参考。方法:收集1990年1月1日至2020年3月1日PubMed,EMBASE,Web of Science,CENTRAL和CNKI等数据库关于研究含锶脱敏牙膏对DH的随机对照试验(RCT)文献,运用Stata 14.0软件对提取的所有文献数据进行Meta分析。结果:共纳入8篇RCT文献,根据8项研究的最长试验周期,对含锶脱敏牙膏和对照组牙膏干预后进行探诊及空气喷吹检测差异进行Meta分析,试验组与对照组在探诊、空气检测敏感值之间比较,差异均无统计学意义(P>0.05);根据试验时间长短、结局指标分类,分别合并即刻、≤1、2、4、6、8、12周的探诊敏感、空气检测敏感值进行亚组分析,结果显示试验组与对照组在探诊、空气检测敏感值之间比较,差异均无统计学意义(P>0.05)。结论:含锶脱敏牙膏和对照组牙膏相比,不能更有效地减轻DH,需要更多的研究来进一步验证其对缓解DH的效果。

Objective To evaluate the therapeutic effect of strontium containing desensitizing toothpaste on dentin hypersensitivity(DH)using Meta-analysis,and provide reference for clinical treatment.Methods The randomized controlled trials(RCTs)literature on the effects of strontium containing desensitizing toothpaste on DH were collected from PubMed,EMBASE,Web of Science,Central,and CNKI databases from January 1,1990 to March 1,2020.Stata 14.0 software was used for Meta-analysis of all the literature data extracted.Results A total of 8 RCT articles were included.Based on the longest trial period of the 8 studies,a meta-analysis was conducted on the differences in probing and air spray detection between strontium containing desensitized toothpaste and control desensitized toothpaste.There was no statistical significance in sensitivity values of probing and air detection between the test group and the control group(P>0.05).According to the duration of the experiment and the classification of outcome indicators,subgroup analysis was conducted by combining the sensitivity values of immediate,≤1,2,4,6,8,and 12 weeks for probing and air detection.The results showed that there was no statistically significant difference between the experimental group and the control group in the sensitivity values of probing and air detection(P>0.05).Conclusion Compared with the control group toothpaste,strontium containing desensitizing toothpaste cannot reduce DH effectively,and more studies are needed to further verify its effectiveness in relieving DH.