孕中期双胎妊娠孕妇血清E2、P、β–HCG联合检测对母婴结局的判断价值

Analysis of the Predictive Value of Combined Detection of Serum E2,P,andβ-HCG in the Second Trimester of Twin Pregnancy for Maternal and Fetal Outcomes

目的:探讨孕中期双胎妊娠孕妇血清雌二醇(E2)、孕酮(P)、人绒毛膜促性腺激素β(β–HCG)联合检测对母婴结局的判断价值。方法:选取2018年6月至2021年3月在汝州市妇幼保健院接受正规产检的孕中期双胎妊娠孕妇60例纳入双胎组,另选取同期在汝州市妇幼保健院产检的孕中期单胎妊娠孕妇98例纳入单胎组,比较两组孕妇孕中期血清E2、P、β–HCG水平,根据分娩结局将双胎组划分为正常亚组、单胎不良亚组与双胎不良亚组,分析双胎组孕妇孕中期血清E2、P、β–HCG水平与母婴结局的相关性。结果:双胎组孕妇孕中期血清β–HCG、E2、P水平均高于单胎组孕妇,差异具有统计学意义(P<0.05);双胎不良亚组、单胎不良亚组孕妇血清β–HCG、E2、P水平均低于正常亚组,且双胎不良亚组孕妇低于单胎不良亚组,差异具有统计学意义(P<0.05);母亲不良结局、胎儿不良结局与孕妇孕中期血清β–HCG、E2、P水平具有较高负相关性,差异具有统计学意义(P<0.05)。结论:双胎妊娠孕妇孕中期血清E2、P、β–HCG水平高于单胎妊娠,双胎妊娠母婴不良结局风险随着孕妇血清E2、P、β–HCG水平的异常降低而增大。

Objective To explore the predictive value of combined detection of serum estradiol(E2),progesterone(P),andβ-human chorionic gonadotropin(β-HCG)in the second trimester of twin pregnancy for maternal and fetal outcomes.Methods A total of 60 twin pregnancies in the second trimester who underwent regulaRprenatal examination at Ruzhou Maternal and Child Health Hospital from June 2018 to March 2021 were included in the twin group.Additionally,98 singleton pregnancies in the second trimester who underwent prenatal examination at the same hospital during the same period were included in the singleton group.The levels of serum E2,P,andβ-HCG in the second trimester were compared between the two groups.According to the delivery outcomes,the twin group was divided into normal subgroups,singleton adverse subgroups,and twin adverse subgroups.The correlation between the levels of serum E2,P,andβ-HCG in the second trimester and maternal and fetal outcomes in the twin group was analyzed.Results The levels of serumβ-HCG,E2,and P in the second trimester of the twin group were higher than those in the singleton group,with statistically significant differences(P<0.05).The levels of serumβ-HCG,E2,and P in the singleton adverse subgroups and twin adverse subgroups were lower than those in the normal subgroups,and the levels in the twin adverse subgroups were lower than those in the singleton adverse subgroups,with statistically significant differences(P<0.05).There was a high negative correlation between maternal and fetal adverse outcomes and the levels of serumβ-HCG,E2,and P in the second trimester,with statistically significant differences(P<0.05).Conclusion The levels of serum E2,P,andβ-HCG in the second trimester of twin pregnancy are higher than those in singleton pregnancy.The risk of adverse outcomes in twin pregnancy increases with the abnormal reduction of serum E2,P,andβ-HCG levels.