猴痘病毒B.1谱系遗传分支、毒力基因及蛋白功能

Genetic branches,virulence genes,and protein functions of the mpox virus lineage B.1

2022年以来,猴痘疫情在全球暴发和流行。相较以往的猴痘病毒,2022年流行的猴痘毒株传播能力和宿主适应性等明显增强,猴痘B.1谱系毒株已成为全球猴痘疫情流行的主要毒株。为此,本文对猴痘病毒B.1谱系遗传分支、毒力基因及蛋白功能进行综述,并就部分基因产物的蛋白功能进行了注释,以期为猴痘疫情的科学防控提供参考。

Mpox virus has been outbreak and prevalent in many countries worldwide since 2022.Compared with the previous mpox virus strains,the 2022 epidemic mpox strains had gained significantly enhanced transmission ability and host adaptability,and the mpox lineage B.1 strains had become the dominant strains in the global epidemic of mpox.In this paper,we reviewed the genetic branches,virulence genes and protein functions of the mpox B.1 strains,and annotated the protein functions of some of the gene products,with an attempt to provide reference for the scientific prevention and control of mpox epidemics.