南征教授应用消渴安汤联合“一则八法”治疗消渴病临床观察

Clinical observation on the effect of Xiaoke'an Decoction combined with"one principle and eight methods"in the treatment of diabetes by Professor Nan Zheng

目的 观察南征教授运用消渴安汤联合“一则八法”治疗消渴病的临床疗效。方法 选择2011年1月-2023年6月期间就诊于长春中医药大学附属医院南征教授工作室的2 219例消渴病患者作为研究对象。根据随机对照原则将其分为对照组与治疗组,对照组889例,治疗组1 330例,对照组以消渴安汤加减作为基础治疗,治疗组在对照组的基础上联合“一则八法”进行综合治疗。观察2组患者治疗前后的空腹血糖、餐后2 h血糖、糖化血红蛋白及中医证候积分的变化情况。结果 2个疗程治疗后,治疗组总有效率优于对照组,差异有统计学意义(P <0.05);2组患者的空腹血糖(FBG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(GHb)及中医证候积分的水平均低于治疗前,差异有统计学意义(P <0.05)。结论 中药联合“一则八法”综合管控可显著降低空腹血糖、餐后2 h血糖、Hb Alc水平,有效强化患者的自我管理效能及延缓患者的病情发展,从而提高患者的生活质量。

Objective To observe the clinical efficacy of Xiaoke'an Decoction combined with the therapy of"one principle and eight methods"in the treatment of diabetes by Professor Nan Zheng.Methods A total of 2219 diabetes patients admitted to the Professor Nan Zheng's Studio at the Affliated Hospital of Changchun University of Chinese Medicine from January 2011 to June 2023 were selected as the study subjects.According to the principle of random control,they were divided into a control group and a study group,with 889 cases in the control group and 1330 cases in the study group.The control group was given modified Xiaoke'an Decoction as its basic treatment,while the study group was managed comprehensively by combining the therapy of"one principle and eight methods"on the basis of the control group.The changes in fasting blood glucose(FBG),2-hour postprandial blood glucose(2hPG),glycosylated hemoglobin(GHb),and TCM symptom scores were observed in the two groups before and after treatment.Results After two courses of treatment,the total effective rate of the study group was 87.07%,better than that of the control group(75.03%),with a statistically significant difference(P<0.05).The levels of FBG,2hPG,GHb,and TCM symptom scores of the two groups were lower than those before treatment,with a statistically significant difference(P<0.05).After treatment,the clinical TCM symptoms and signs improved in both groups,and the study group was significantly better than the control group,with a statistically significant difference(P<0.05).Conclusion The combination of Chinese medicine and the comprehensive management with"one principle and eight methods"can significantly reduce the levels of fasting blood glucose,2-hour postprandial blood glucose,and HbAlc,effectively strengthen the patient's self-management efficiency and delay the development of the disease,thereby improving their quality of life.