梅毒合并肛周部位疾病的构成及相关因素研究

The Composition and Related Factors of Syphilis Complicated with Perianal Diseases

目的探讨梅毒、肛周部位疾病的构成及相关因素。方法回顾性分析2020年6月至2022年7月在本院肛肠门诊、特需门诊进行诊治的患者29063例作为研究对象。根据其梅毒血清特异性抗体与梅毒非特性抗体测定结果是否为阳性将患者分为合并组与肛周组,合并组即为梅毒合并肛周部位疾病患者,共217例,肛周组为仅患有肛周部位疾病患者,共有28792例。所有患者入院后均完善相关检查,帮助患者确诊,必要时对患者行病理检查。查阅患者临床资料,统计并记录患者的年龄、文化程度、睡眠时间、体育锻炼、饮食习惯、饮酒、吸烟、坐站蹲时间、辛辣食物、性伴侣,对上述因素进行单因素及多因素Logistic分析。结果其中排在前三位的分别为混合痔(72例)、肛瘘(52例)、便血(15例),分别占33.18%、23.96%及6.91%;单因素结果表明梅毒、肛周部位疾病发生率与年龄、文化程度、吸烟差异无统计学意义;与睡眠时间、饮酒、辛辣食物、体育锻炼、性伴侣个数差异具有统计学意义(P<0.05)。而多因素Logistic分析梅毒、肛周部位疾病发生率与睡眠时间、体育锻炼、辛辣食物、性伴侣个数差异均具有统计学意义(P<0.05)。结论梅毒、肛周部位疾病类型较多,且影响因素相对较多,应根据危险因素制定有效的干预措施,降低疾病发生率。

Objective To explore the composition and related factors of syphilis and perianal diseases.Methods From June,2020 to July 2022,29063 patients who were diagnosed and treated in the Anorectal Clinic and Special Needs Clinic of our hospital were retrospectively analyzed as research objects.According to whether the test results of syphilis serum specific antibody and syphilis non-specific antibody were positive,these patients were divided into the combined group and perianal group.There were 28792 patients with peripheral diseases.All patients were admitted to the hospital to complete relevant examinations for a confirmed diagnosis,and pathological examinations were performed on patients when necessary.We obtained patients’clinical data,demographic record including age,education level,sleep time,physical exercise,eating habits,drinking,smoking,sitting,standing and squatting time,spicy food,sexual partner,and performed single factor and multivariate logistic analysis.Results Among all factors,the top three were mixed hemorrhoids(72 cases),anal fistula(52 cases),and hematochezia(15 cases),accounting for 33.18%,23.96%and 6.91%respectively;Single factor results showed that syphilis and perianal diseases occurrence had no statistically significant difference between the rate and age,education level,and smoking;There were statistically significant differences with sleep time,alcohol consumption,spicy food,physical exercise,and the number of sexual partners(P<0.05).The multivariate logistic analysis showed statistically significant differences in the incidence of syphilis,perianal diseases,sleep time,physical exercise,spicy food,and number of sexual partners(P<0.05).Conclusion There are multiple types of diseases in the vulva and perianal area with many influencing factors.Effective intervention measures should be formulated according to risk factors to reduce the incidence rate of diseases.