摘要
颞下颌关节骨关节炎(TMJOA)是颞下颌关节退行性疾病,发病率高,严重影响患者生活质量,但其发病机制不明。研究发现血管生成参与TMJOA的进展并与关节软骨基质降解、软骨下骨硬化、骨赘形成,疼痛等密切相关。本文综述近年来TMJOA中血管生成研究相关进展,并为TMJOA的治疗提供展望。
Temporomandibular joint osteoarthritis(TMJOA)is a degenerative disease of temporomandibular joint,which has a high incidence and affects the quality of patients′life.While the pathogenesis of TMJOA remains unclear.It has been found that angiogenesis is involved in the development of TMJOA and it is closely related to the degradation of articular cartilage matrix,subchondral ossification,osteophyte formation and pain.This article reviews the recent advances in the study of angiogenesis in TMJOA,and provides a prospect for the treatment of TMJOA.
作者
郑芷新
房维
Zheng Zhixin;Fang Wei(State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School&Hospital of Stomatology,Wuhan University,Wuhan 430079,China;Department of Oral and Maxillofacial Trauma and Temporomandibular Joint Surgery,School&Hospital of Stomatology,Wuhan University,Wuhan 430079,China)
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2024年第3期263-266,共4页
Chinese Journal of Stomatology
基金
湖北省自然科学基金(2021CFB363)。
关键词
颞下颌关节
骨关节炎
血管生成
血管内皮生长因子类
退行性改变
Temporomandibular joint
Osteoarthritis
Angiogenesis
Vascular endothelial growth factors
Degeneration
