男性酒精依赖患者的子女的危险性饮酒与决策能力的相关性

Correlation between risky drinking and decision-making ability in offspring of fathers with alcohol dependence

目的:探索男性酒精依赖患者的子女(OFAD)的危险性饮酒与决策能力的相关性。方法:采用病例对照研究方法,根据酒精使用障碍筛查量表得分(AUDIT,划界分为7)将OFAD分为“危险性饮酒组”(n=29)和“非危险性饮酒组”(n=43)。采用爱荷华博弈任务(IGT)评估被试的决策能力。使用协方差分析比较两组间的IGT差异,使用多因素logistic回归探讨决策能力与危险性饮酒的关联性。结果:危险性饮酒组与非危险性饮酒组IGT总成绩差异无统计学意义(P>0.05);危险性饮酒组较非危险性饮酒组block5选择牌2的试次更少[(3.8±2.5)v.s.(5.7±3.1),P<0.05];控制协变量后,危险性饮酒仍与block5牌2选择试次存在正关联(OR=0.72,95%CI:0.57~0.90,P<0.05)。结论:本研究提示酒精依赖患者的子女(OPAD)中危险性饮酒者决策能力可能更好。

Objective:To investigate the association of risky drinking and decision-making ability among offspring of fathers with alcohol dependence(OFAD).Methods:A case-control study was conducted according to the cutoff of the Alcohol Use Disorder Identification Test(AUDIT)(delimited as 7).OFAD were divided into“risky drinking group”(n=29)and“non-risky drinking group”(n=43).The Iowa Gambling Task(IGT)was used to evaluate the decision-making ability.Covariance analysis was used to compare differences of IGT between the two groups,and multivariate logistic regression was used to explore the association between risky drinking and decision making ability.Results:There was no significant difference in total scores of IGT between the risky drinking group and the non-risky drinking group(P>0.05).Risky drinking group had less Selection 2 in block 5 of IGT[(3.8±2.5)v.s.(5.7±3.1),P<0.05]than non-risky drinking group.Selection 2 in block 5 was still associated with risky drinking after controlling the covariates(OR=0.72,95%CI:0.57~0.90,P<0.05).Conclusion:This study indicates that risky drinking group in offspring of parents with alcohol dependence may have better decision-making ability.