基于数据挖掘探讨中医药治疗健忘用方研究

Research on Traditional Chinese Medicine Treatment for Amnesia Based on Data Mining

目的用数据挖掘手段研究健忘病症用方侧重和思路。方法搜索并筛选《中医方剂大辞典》与《中华医典》中治疗健忘的方剂,利用相应软件分析四气五味、性味归经,并通过相应的数据挖掘算法手段,研究治疗“健忘”的方剂用药组方配伍规律并分析讨论其内在思路。结果共收集272首方剂,所含药物277种中药,高频药物为人参、远志、茯苓等。四气以温药为主,五味以甘、苦、辛居多,归经以心、肾、脾、肺、肝降序排列。药物关联规则分析中核心药对为11组,高频药物因子分析共提取9个公因子,系统聚类分析归为6大类。结论健忘病症治疗以虚证为主,尤其注重补益心、肾、脾三脏,用药多用甘温之品,用辛、苦温之品兼顾痰、瘀、风的祛除,并配合开窍醒神、养心安神、温阳利水共治健忘病症。

Objective To use data mining methods to study the focus and ideas of prescription for amnesia.Methods Search and screen the prescriptions for treating amnesia in the Dictionary of Traditional Chinese Medicine Prescriptions and Chinese Medical Dictionary.Use corresponding software to analyze the four Qi and five flavors,as well as the nature and taste of the meridians.Through corresponding data mining algorithm methods,study the combination rules of prescriptions for treating“amnesia”and analyze and discuss their underlying ideas.Results As a result,a total of 272 prescriptions were collected,containing 277 types of traditional Chinese medicine,including high-frequency drugs such as ginseng,polygala,and poria cocos.The four Qi are mainly composed of warming herbs,while the five flavors are mainly sweet,bitter,and spicy.The meridians are arranged in descending order of heart,kidney,spleen,lung,and liver.In drug association rule analysis,the core drug pairs are 11 groups,and high-frequency drug factor analysis extracts a total of 9 common factors,which are classified into 6 categories through systematic clustering analysis.Conclusion The treatment of amnesia is mainly based on deficiency syndrome,with a particular emphasis on tonifying the heart,kidney,and spleen organs.Medications often use sweet and warm ingredients,while using spicy,bitter and warm ingredients to eliminate phlegm,blood stasis,and wind.It is also combined with opening the orifices and awakening the mind,nourishing the heart and calming the mind,warming Yang and diuresis to treat amnesia.