炎症标志物在原发性胆汁性胆管炎患者中的预后作用

Prognostic role of inflammatory markers in patients with primary biliary cholangitis

目的探讨炎性标志物是否能预测原发性胆汁性胆管炎(PBC)患者的预后。方法采用回顾性研究,通过Spearman相关性分析探索炎性标志物与肝功能之间的相关性,进一步利用X-tile软件确定炎性标志物的最佳截断值。分别采用Log-rank检验比较各炎性标志物对预后的影响并绘制各自的Kaplan-Meier曲线,最后通过Cox生存分析法进一步分析影响预后的炎性标志物。结果γ谷氨酰转移酶与血小板的比值(GPR)是影响PBC患者预后的独立危险因素,高GPR(≥1.9)可提示患者预后不佳。结论基线时GPR水平与PBC患者的组织学分期和不良预后相关,GPR(≥1.9)可以作为一个独立的预测因子提示PBC患者预后不佳。

Objective To investigate whether inflammatory markers can predict the prognosis of patients with primary biliary cholangitis(PBC).Methods A retrospective study was conducted to explore the correlation between inflammatory markers and liver function through Spearman correlation analysis.The optimal cut-off value of inflammatory markers was determined by X-tile software.The effects of each inflammatory marker on prognosis were compared by Log-rank test and their respective Kaplan-Meier curves were drawn,and finally the inflammatory markers affecting prognosis were further analyzed by Cox survival analysis.Results The gamma-glutamyl transpeptidase-to-platelet ratio(GPR)was an independent risk factor for the prognosis of PBC patients,and higher GPR(≥1.9)prompted a poor prognosis.Conclusion GPR level at baseline has a correlation with the histological stage and poor prognosis of PBC patients.GPR(≥1.9)can be utilized as an independent predictor to suggest negative prognosis of PBC patients.