T细胞耗竭在乙型肝炎病毒相关疾病中的研究进展

导出

摘要乙型肝炎病毒(hepatitis B virus,HBV)感染是全球公共卫生面临的最大威胁之一,尽管有预防性疫苗,但每30秒就有一人死于HBV相关性疾病[1].世界卫生组织的资料显示,全球约有2.57亿人患有慢性乙型肝炎(chronic hepatitis B,CHB),但这数字普遍被认为是低估的,且CHB与肝硬化、肝细胞癌(hepatocellular carcinoma,HCC)和肝纤维化等发生发展密切相关[2-3].

作者贾文浩宋静娟马义磊张钧崔大伟

机构地区浙江大学医学院附属邵逸夫医院检验科、医学精准检验与监测研究实验室浙江大学医学院附属第一医院输血科

出处《中华危重症医学杂志（电子版）》 CAS CSCD 2023年第6期501-509,共9页 Chinese Journal of Critical Care Medicine:Electronic Edition

基金国家自然科学基金(81871709)。

关键词预防性疫苗乙型肝炎病毒全球公共卫生肝细胞癌相关性疾病慢性乙型肝炎肝纤维化肝硬化

分类号 R512.62 [医药卫生—内科学]

引文网络
相关文献

参考文献8

1Corey Saraceni,John Birk.A Review of Hepatitis B Virus and Hepatitis C Virus Immunopathogenesis[J].Journal of Clinical and Translational Hepatology,2021,9(3):409-418. 被引量：6
2Ziqing Zeng,Feng Wei,Xiubao Ren.Exhausted T cells and epigenetic status[J].Cancer Biology & Medicine,2020,17(4):923-936. 被引量：6
3Dongyao Wang,Binqing Fu,Xiaokun Shen,Chuang Guo,Yanyan Liu,Junfei Zhang,Rui Sun,Ying Ye,Jiabin Li,Zhigang Tian,Haiming Wei.Restoration of HBV-specific CD8+T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-αtherapy[J].Signal Transduction and Targeted Therapy,2021,6(12):3684-3696. 被引量：6
4Timothy N.J.Bullock.CD40 stimulation as a molecular adjuvant for cancer vaccines and other immunotherapies[J].Cellular & Molecular Immunology,2022,19(1):14-22. 被引量：4
5Qiqi Zhang,Hui Huang,Aijun Sun,Chunyan Liu,Zhidong Wang,Feifan Shi,Wei Duan,Xueying Sun,Qi Wang,Ping Sun,Chunwen Pu,Yong Zhang.Change of Cytokines in Chronic Hepatitis B Patients and HBeAg are Positively Correlated with HBV RNA, Based on Real-world Study[J].Journal of Clinical and Translational Hepatology,2022,10(3):390-397. 被引量：3
6Tian-Yang Li,Yang Yang,Guo Zhou,Zheng-Kun Tu.Immune suppression in chronic hepatitis B infection associated liver disease: A review[J].World Journal of Gastroenterology,2019,25(27):3527-3537. 被引量：79
7中华医学会肝病学分会,中华医学会感染病学分会,尤红,王福生,李太生,孙亚朦,徐小元,贾继东,南月敏,王贵强,侯金林,魏来,段钟平,庄辉.慢性乙型肝炎防治指南(2022年版)[J].中华临床感染病杂志,2022,15(6):401-427. 被引量：69
8Antonio Bertoletti,Patrick T Kennedy.The immune tolerant phase of chronic HBV infection： new perspectives on an old concept[J].Cellular & Molecular Immunology,2015,12(3):258-263. 被引量：46

二级参考文献53

1Peng Hu,Jia Shang,Wenhong Zhang,Guozhong Gong,Yongguo Li,Xinyue Chen,Jianning Jiang,Qing Xie,Xiaoguang Dou,Yongtao Sun,Yufang Li,Yingxia Liu,Guozhen Liu,Dewen Mao,Xiaoling Chi,Hong Tang,Xiaoou Li,Yao Xie,Xiaoping Chen,Jiaji Jiang,Ping Zhao,Jinlin Hou,Zhiliang Gao,Huimin Fan,Jiguang Ding,Dazhi Zhang,Hong Ren.HBsAg Loss with Peg-interferon Alfa-2a in Hepatitis B Patients with Partial Response to Nucleos(t)ide Analog:New Switch Study[J].Journal of Clinical and Translational Hepatology,2018,6(1):25-34. 被引量：91
2Xie-Er Liang,Yong-Peng Chen.Clinical Application of Vibration Controlled Transient Elastography in Patients with Chronic Hepatitis B[J].Journal of Clinical and Translational Hepatology,2017,5(4):368-375. 被引量：13
3姚光弼,陈成伟,陆纬伦,任红,谭德明,王宇明,徐道振.恩替卡韦和拉米夫定治疗慢性乙型肝炎二年病毒学、血清学和生化结果的随机对比研究[J].肝脏,2008,13(1):2-6. 被引量：48
4Tao Gu,Yibei Zhu,Cheng Chen,Min Li,Yongjing Chen,Gehua Yu,Yan Ge,Shiyong Zhou,Huan Zhou,Yong Huang,Yuhua Qiu,Xueguang Zhang.Fine-Tuned Expression of Programmed Death 1 Ligands in Mature Dendritic Cells Stimulated by CD40 Ligand is Critical for the Induction of an Efficient Tumor Specific Immune Response[J].Cellular & Molecular Immunology,2008,5(1):33-39. 被引量：3
5王泰龄,刘霞,周元平,何静雯,张晶,李宁章,段钟平,王宝恩.慢性肝炎炎症活动度及纤维化程度计分方案[J].中华肝脏病杂志,1998,6(4):195-197. 被引量：388
6姜立胜,李用国,陈姝,兰英华.抗病毒治疗对乙型肝炎相关慢加急性肝衰竭近期及远期疗效的影响[J].临床肝胆病杂志,2013,29(2):110-113. 被引量：23
7徐元勇,刘慧慧,王勇,郝荣章,李振军,宋宏彬.中国控制乙型肝炎的下一步工作：重点应放在控制围产期病毒传播[J].英国医学杂志中文版,2013,16(5):282-283. 被引量：13
8Hanjie Li,Qiuyu Zhuang,Yuze Wang,Tianyi'ng Zhang,Jinghua Zhao,Yali Zhang,Junfang Zhang,Yi Lin,Quan Yuan,Ningshao Xia,Jiahuai Han.I-IBV life cycle is restricted in mouse hepatocytes .~xpressing human NTCP[J].Cellular & Molecular Immunology,2014,11(2):175-183. 被引量：16
9中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组,李兰娟,韩涛.肝衰竭诊治指南(2018年版)[J].中华肝脏病杂志,2019,27(1):18-26. 被引量：443
10杨瑞华,李芹,陈玮.扶正化瘀胶囊治疗慢性乙型肝炎肝纤维化疗效的Meta分析[J].中华肝脏病杂志,2015,23(4):295-296. 被引量：50

共引文献209

1Ruth Broering,Xufeng Luo,Jia Liu,Mengji Lu.Controversial: Early Innate Responses to Hepatitis B Virus Infection,an Explanation for Viral Persistence?[J].Virologica Sinica,2021,36(1):163-166. 被引量：2
2周小燕,庞博,张晏,丁显平.microRNA对乙型肝炎病毒相关肝癌诊断价值的Meta分析[J].实用预防医学,2023,30(2):222-226.
3司进枚,王茜,陈民,徐小国,李青青.恩替卡韦在乙肝中的治疗效果及其对免疫细胞的功能影响[J].世界最新医学信息文摘,2019,0(104):11-13.
4Yuhui Miao,Yuning Liu,Haidong Tang,Zemin Zhang.Dendritic cell maturation in the tumor microenvironment[J].National Science Open,2023,2(6):42-64.
5Yujia Li,Shilin Li,Xiaoqiong Duan,Chunhui Yang,Min Xu,Limin Chen.Macrophage Phenotypes and Hepatitis B Virus Infection[J].Journal of Clinical and Translational Hepatology,2020,8(4):424-431. 被引量：5
6Tianzhong Pan,Peng Ding,Aijie Huang,Baolin Tang,Kaidi Song,Guangyu Sun,Yue Wu,Shiying Yang,Xingchi Chen,Dongyao Wang,Xiaoyu Zhu.Reconstitution of double-negative T cells after cord blood transplantation and its predictive value for acute graft-versus-host disease[J].Chinese Medical Journal,2024,137(10):1207-1217.
7王飚,赵临襄,计志忠.2-烷基-5(N,N-二取代胺甲基)-2-环戊烯酮类化合物的合成及其抗癌活性[J].中国药物化学杂志,2000,10(1):26-28. 被引量：4
8Antonio Bertoletti,Fu-Sheng Wang.Overview of the special issue on HBV immunity[J].Cellular & Molecular Immunology,2015,12(3):253-254. 被引量：3
9谌平,何成宜,陈志英.合成免疫策略治疗慢性乙肝病毒感染综述[J].集成技术,2015,4(4):45-54. 被引量：1
10赵宝生,董金玲,谢放,张龙,温慧敏.硫普罗宁联合替比夫定治疗慢性乙型肝炎的疗效观察[J].现代药物与临床,2016,31(1):62-65. 被引量：14

1沈昱灿,施均.耗竭T细胞命运决定的分子机制研究新进展[J].国际输血及血液学杂志,2023,46(6):491-496.
2付宝云,熊渝婷,王文畅,邓亚,郭畅,杨武才,王春艳,纪冬,王建军.丙氨酸转氨酶正常的慢性乙型肝炎患者肝组织学改变的关联因素分析[J].解放军医学院学报,2023,44(11):1218-1223. 被引量：1
3Jie-Li Hu,Ai-Long Huang.Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics[J].Virologica Sinica,2024,39(1):9-23. 被引量：1
4陈曦,江峰,张岩峰,刘静,刘晶晶,冯卉,皋月娟,于杰,刘方义.慢性乙肝患者发生急性药物性肝损伤的超声特征分析[J].解放军医学院学报,2023,44(11):1200-1205. 被引量：1

中华危重症医学杂志（电子版）

2023年第6期

浏览历史

内容加载中请稍等...

T细胞耗竭在乙型肝炎病毒相关疾病中的研究进展

参考文献8

二级参考文献53

共引文献209

相关作者

相关机构

相关主题

浏览历史