冠心病患者冠状动脉斑块超声影像学特征与血清IL-22水平的关系

Relationship Between Ultrasonic Imaging Characteristics of Coronary Artery Plaque and Serum IL-22 Level in Patients with Coronary Heart Disease

目的 分析冠心病患者冠状动脉斑块超声影像学特征与血清白介素-22(interleukin-22,IL-22)水平相关性。方法 入选临床疑诊冠心病患者147例,根据患者临床症状、心电图表现和冠状动脉造影检查结果,分为对照组38例、稳定型心绞痛(stable angina pectoris,SAP)组62例、不稳定型心绞痛(unstable angina pectoris,UAP)组47例。测定患者血管内超声情况并比较SAP组与UAP组组间差异,ELISA法测定并比较受试者血清IL-22水平,Pearson法分析SAP组与UAP组两组患者血清IL-22水平与冠状动脉斑块超声影像学特征的相关性。结果 与SAP组相比,UAP组患者脂质性斑块占比、易损斑块数占比、病变部位血管外弹力膜面积(EEMA)、病变部位斑块面积(PA)、病变部位面积狭窄率(LAS)、血管重构指数(RI)、斑块大小、脂核或无回声带大小升高,纤维帽厚度降低(P <0.05)。与对照组相比,SAP组、UAP组患者血清IL-22水平升高(P<0.05)。与SAP组相比,UAP组患者血清IL-22水平升高(P <0.05)。冠心病患者血清IL-22水平与病变部位EEMA、病变部位PA、病变部位LAS、RI、斑块大小、脂核或无回声带大小呈正相关(r=0.635、0.578、0.520、0.563、0.483、0.511,P <0.05),与纤维帽厚度呈负相关(r=–0.438,P <0.05);与稳定斑块组患者相比,易损斑块组患者血清IL-22水平升高(P <0.05)。结论 血清IL-22水平与冠心病患者斑块类型有关,血清IL-22可能是易损斑块发生的标志物。

Objective To analyze the correlation between the ultrasonic imaging characteristics of coronary artery plaque and the level of serum interleukin-22(IL-22) in patients with coronary heart disease.Methods A total of 147 patients with suspected coronary artery disease were enrolled.According to the patients' clinical symptoms,electrocardiogram performance and coronary angiography examination results,they were divided into 38 cases of control group,62 cases of stable angina pectoris(SAP) group and 47 cases of unstable angina pectoris(UAP) group.The patients underwent intravascular ultrasound,and compare the differences between SAP and UAP groups,the level of serum IL-22 was measured and compared by ELISA,Pearson method was used to analyze the correlation between serum IL-22 levels and ultrasonic imaging characteristics of coronary plaque in patients with SAP and UAP.Results Compared with SAP group,the percentage of lipid plaque,the percentage of vulnerable plaque,EEMA,PA,LAS,RI,plaque size,fat nucleus or anechoic zone size in UAP group increased(P <0.05),and the thickness of fibrous cap decreased(P <0.05).Compared with the control group,the level of serum IL-22 in SAP group and UAP group were higher(P <0.05).Compared with SAP group,the level of serum IL-22 in UAP group was higher(P <0.05).The serum IL-22 level in patients with coronary heart disease was positively correlated with EEMA,PA,LAS,RI,plaque size,fat nucleus or anechoic zone size(r = 0.635,0.578,0.520,0.563,0.483,0.511;P <0.05),and negatively correlated with fiber cap thickness(r=–0.438,P<0.05);compared with the stable plaque group,the level of serum IL-22 in vulnerable plaque group was higher(P <0.05).Conclusion The level of serum IL-22 is related to the type of plaque in patients with coronary heart disease.Serum IL-22 may be a marker of vulnerable plaque in patients with coronary heart disease.