摘要
目的分析心脏彩超联合血清心脏肌球蛋白结合蛋白C(cMyBP-C)检测对急性心肌梗死的临床诊断价值。方法选取2020年8月至2022年9月在我院诊治的125例急性心肌梗死患者作为观察组,及同期120例健康体检志愿者作为对照组进行研究。采用酶联免疫吸附(ELISA)法对血清cMyBP-C水平进行测定。受试者工作特征(ROC)曲线分析血清cMyBP-C水平对急性心肌梗死的诊断价值;采用四格表分析心脏彩超联合血清cMyBP-C水平检测对急性心肌梗死的诊断价值。结果观察组左室舒张末容积、左室收缩末容积大于对照组,左室射血分数小于对照组(P<0.05)。与对照组相比,观察组血清cMyBP-C水平显著升高(P<0.05)。血清cMyBP-C诊断急性心肌梗死的曲线下面积(AUC)为0.921,截断值为43.78μg/L;心脏彩超联合血清cMyBP-C诊断急性心肌梗死的灵敏度为95.20%、特异度为86.67%、准确度为91.02%,其诊断效能高于心脏彩超、血清cMyBP-C单独检测。结论急性心肌梗死患者血清cMyBP-C水平升高,对急性心肌梗死具有一定的诊断价值,联合心脏彩超可明显提高对急性心肌梗死的诊断价值。
Objective To analyze the clinical diagnostic value of color Doppler ultrasound combined with serum cardiac myosin binding protein C(cMyBP-C) in acute myocardial infarction.Methods A total of 125 patients with acute myocardial infarction diagnosed and treated in our hospital from August 2020 to September 2022 were selected as the observation group,and 120 healthy volunteers in the same period as the control group.Enzyme linked immunosorbent assay(ELISA) was used to determine the serum cMyBP-C level.The diagnostic value of serum cMyBP-C level for acute myocardial infarction was analyzed by ROC curve;the diagnostic value of color Doppler echocardiography combined with serum cMyBP-C level for acute myocardial infarction was analyzed with four grid table.Results The left ventricular end diastolic volume and left ventricular end systolic volume in the observation group were greater than those in the control group,and the left ventricular ejection fraction was lower than that in the control group(P <0.05).Compared with the control group,the serum cMyBP-C level in the observation group was obviously higher(P <0.05).The area under curve(AUC) of serum cMyBP-C in diagnosis of acute myocardial infarction was 0.921,and the cut-off value was 43.78 μg/L;the sensitivity,specificity and accuracy of cardiac color ultrasound combined with serum cMyBP-C in the diagnosis of acute myocardial infarction were 95.20%,86.67% and 91.02%,respectively,its diagnostic efficacy was higher than that of cardiac color ultrasound and serum cMyBP-C alone.Conclusion The serum cMyBP-C level in patients with acute myocardial infarction is elevated,which has certain diagnostic value for acute myocardial infarction.The combination with color Doppler echocardiography can obviously improve the diagnostic value of acute myocardial infarction.
作者
朱莉
刘丹丹
向导
ZHU Li;LIU Dandan;XIANG Dao(Doppler Ultrasonic Department,Chongqing University Jiangjin Hospital,Chongqing 402260,China;Department of Cardiology,Chongqing University Jiangjin Hospital,Chongqing 402260,China;Clinical Laboratory,The First Affiliated Hospital of Hainan Medical College,Haikou 570102,Hainan,China)
出处
《中国分子心脏病学杂志》
CAS
2023年第6期5785-5789,共5页
Molecular Cardiology of China