造血系统辐射损伤响应相关骨髓间充质干细胞群体异质性研究进展

Research progress on heterogeneity of bone marrow mesenchymal stem cell populations related to hematopoietic system radiation injury repairing

有效救治造血系统辐射损伤是医疗和军事场景中广受关注的现实问题,但目前相关的救治措施仍较为有限。间充质干细胞(MSC)作为骨髓微环境的重要组成成分之一,与造血系统辐射损伤及修复密切相关。目前虽已有较多输注外源性MSC及MSC外泌体促进辐射损伤修复的报道,但涉及辐射损伤后骨髓原位MSC群体的响应规律报道较少。该综述主要针对可能参与造血系统辐射损伤响应的骨髓原位MSC及其群体异质性进行回顾和总结。

Efficient treatment of hematopoietic system radiation injuries that occur in medical and military settings is a real problem that has attracted increasing attention.However,current treatments for hematopoietic system radiation injury are lacking.Mesenchymal stem cells(MSCs)are one of the important components of the bone marrow microenvironment.The role of infusion of exogenous MSCs or their exosomes in promoting hematopoietic system radiation damage repair has been extensively reported.However,there have been relatively few studies on the responses of MSCs in situ in bone marrow after radiation injury.This review focuses on the in situ bone marrow MSC populations that are potentially involved in hematopoietic system radiation injury repair and on the heterogeneity of these MSCs.