摘要
核黄素又称维生素B2,以辅酶形式参与机体氧化还原反应。本文综述了核黄素对成骨细胞分化及骨健康的影响,核黄素缺乏降低股骨骨密度与骨小梁数量、破坏软骨生长板正常形态;体外补充核黄素可上调成骨细胞分化相关信号通路和转录因子表达。
Riboflavin,also known as vitamin B2,closely related to many metabolic processes by acting as cofactors.In this review,we summarized recent advances in the effects of riboflavin on bone health.Riboflavin deficiency reduced femoral bone mineral density and the number of bone trabeculae and damaged the morphology of cartilage growth plate.Riboflavin supplementation up-regulated the expression of signaling pathways and transcription factors of osteoblastic differentiation in vitro.
作者
边祥雨
王艳仙
万旻
高蔚娜
BIAN Xiang-yu;WANG Yan-xian;WAN Min;GAO Wei-na(Institute of Environmental and Operational Medicine,Tianjin 300050,China)
出处
《营养学报》
CAS
CSCD
北大核心
2023年第6期615-618,共4页
Acta Nutrimenta Sinica
基金
国家自然科学基金(No.81973029)。
关键词
核黄素
骨健康
成骨细胞
riboflavin
bonehealth
osteoblasts
