经颅磁刺激诱发脑电图伪迹去除方法的研究进展

Research progress in removal methods of electroencephalography artifacts evoked by transcranial magnetic stimulation

经颅磁刺激(TMS)结合脑电图(EEG)是一种非侵入性研究脑皮质兴奋性和连通性的技术,已在基础研究和临床疾病诊疗中得到了应用。然而,由于TMS脉冲输出诱导的生物和非生物性质的伪迹,TMS-EEG的适用性受到了限制。为了解决这个问题,在过去10年中,研究者从在线实验设计和离线数据后处理2个方面开展研究,开发了多种TMS-EEG伪迹去除方法,取得了很多有价值的成果。主要介绍了目前可用的TMS-EEG伪迹去除方法,为促进TMS-EEG在基础研究和临床疾病诊疗中的应用提供帮助。

Transcranial magnetic stimulation(TMS)combined with electroencephalography(EEG)is a non-invasive technique for studying the excitability and connectivity of the brain cortex,which has been applied in basic scientific research and clinical disease assessment.However,the applicability of TMS-EEG is limited due to artifacts of both biological and abiotic nature induced by TMS pulse output.To address this issue,in the past decade,researchers have developed various TMS-EEG artifact removal methods from two perspectives,including online experimental design and offline data post-processing,and have achieved numerous valuable results.In this paper,the currently available TMS-EEG artifact removal methods are reviewed to facilitate the application of TMS-EEG in basic research and clinical disease diagnosis and treatment.