早发性卵巢功能不全与甲状腺自身免疫的研究进展

Research progress on the correlation between premature ovarian insufficiency and thyroid autoimmunity

早发性卵巢功能不全(premature ovarian insufficiency,POI)是一种严重影响育龄期女性身心健康的常见生殖障碍性疾病。由于POI病因高度异质性,其发病机制尚不明确。大量研究表明,免疫因素在其发生发展过程具有重要作用,逐渐成为POI病因学研究的重要方向之一。据估计,约有4%~30%的POI病例与自身免疫性疾病相关,其中甲状腺自身免疫(thyroid autoimmunity,TAI)最常见,约占POI自身免疫性病例的30%~40%。因此,针对引起POI的TAI性因素及具体机制的研究,将有助于POI的早期发现、早期干预,改善卵巢功能。文章综述了引发POI的TAI因素,以期为深入研究POI的生理病理机制提供新思路。

Premature ovarian insufficiency(POI)is one of the most ordinary reproductive endocrine disorders that seriously affects the physical and mental health of women in childbearing age.Due to the highly heterogeneous etiology of POI,its pathogenesis remains unclear.A large number of studies have shown that immune factors play an important role in the pathogenesis and development of POI,and have gradually become one of the important directions in the etiology of POI.It is estimated that approximately 4%~30%of POI patients are associated with autoimmune diseases,with thyroid autoimmune(TAI)being the most common,accounting for about 20%~30%of POI autoimmune cases.Therefore,the research on TAI factors and specific mechanisms causing POI will be helpful for early detection and timely intervention of related factors to improve ovarian function.TAI factors causing POI were reviewed in order to provide ideas for further study of the physiological and pathological mechanism of POI.