基于CiteSpace对1996至2023年间纳米技术在脓毒症中应用研究现状的可视化分析

Visual analysis of the current research status in the field of nanotechnology in sepsis from 1996 to 2023 based on CiteSpace

目的探究1996至2023年纳米技术在脓毒症中应用的相关研究热点和趋势.方法从科学网(Web of Science)核心数据库中提取与脓毒症纳米技术应用相关的文献.利用CiteSpace软件对年度发表数、引用、作者合作、机构合作、国家合作和共现关键词等指标进行评估和可视化.结果共检索出1271篇出版物.1996至2023年,与脓毒症中纳米技术有关的研究数量和引用次数都有明显增加,年发文量从1996年的1篇上升到2022年的205篇,平均增长率为23.7%.说明纳米技术在脓毒症中应用的相关研究正逐渐成为研究者关注的热点.1996至2006年,发文量呈现缓慢上升趋势,总体态势趋于平稳.2006至2023年,发文量增长较快,2022年发文量达高峰,为205篇.发文量排名前10位的机构中,最多的是中国科学院,为32篇;排名前10位的作者中,发文量最多的是Amin,为14篇.我国以430篇出版物(33.8%)和7539次引用在评估指标中排名第一.其次是美国,以276篇论文和9859次引用位居第二.印度、韩国和德国紧随其后.中国科学院成为我国发文量的领军机构(32篇),其次是天津大学(26篇).较活跃的关键词聚类是"复合材料(composites)""激活(activation)""捕获(capture)""感染(infection)""药物递送(drug delivery)""传感器(sensor)"和"生物标志物(biomarkers)".研究热点主要集中在诊断和治疗领域.结论纳米技术在促进脓毒症治疗方面应用前景广阔,其研究热点正从本身的抗菌、免疫调节等特性向改造纳米复合物,使其能多功能地靶向脓毒症不同病理机制方向发展.纳米材料的集成凸显了其日益增长的影响力.但学者们多为独立性研究,国家和机构间的合作较少,影响力低.建议加强国内外研究者的合作与交流,促进纳米技术在脓毒症中应用的科学化、规范化发展.

Objective To investigate the hotspots and trends in research related to nanotechnology applications in sepsis from 1996 to 2023.Methods Sepsis-related nanotechnology literature was sourced from the Web of Science core databases,with key metrics like publication count,citations,and various collaborations(author,institutional,national)analyzed.The data,including co-occurring keywords,were visualized using the CiteSpace tool.Results From 1996 to 2023,a total of 1271 publications on nanotechnology in sepsis were retrieved,demonstrating a significant increase in both studies and citations,with the annual publication rate growing from 1 in 1996 to 205 in 2022,averaging an 23.7%growth rate.From 1996 to 2006,the number of articles issued showed a slow upward trend,and the overall trend tends to be stable.From 2006 to 2023,a rapid growth in publications peaked in 2022 with 205 articles.The Chinese Academy of Sciences(CAS)leads the list of institutions with the highest number of publications,with a total of 32 papers.While the most prolific author was Amin with 14 publications.China was the most productive country with 430 publications(33.8%)and 7539 citations,followed by the United States with 276 publications and 9859 citations.India,South Korea and Germany followed.The research hotspots,indicated by keyword clusters like"composites""activation""capture""infection""drug delivery""sensor"and"biomarkers".The research hotspots are mainly in the diagnostic and therapeutic areas.Conclusions Nanotechnology holds great promise in facilitating sepsis treatment,and research hotspots nanomaterials are shifting from traditional antimicrobial and immunomodulatory properties of nanomaterials to the development of multifunctional nanocomplexes targeting diverse pathological mechanisms in sepsis.This transition underlines the expanding role of nanomaterials in this field.Despite their growing influence,current research is predominantly led by independent scholars,lacking extensive national and inter-institutional collaborations,which limits its impact.It is recommended to strengthen the cooperation and communication between domestic and foreign researchers to promote the scientific and standardized development of nanotechnology application in sepsis.