颈脊髓损伤神经源性肠道功能障碍与肠道菌群的关系研究进展

Research progress on the relationship between neurogenic bowel dysfunction and intestinal flora in cervical spinal cord injury

颈脊髓损伤除了造成严重的躯体运动、感觉障碍外,也可导致影响患者生命安全与生活质量的严重并发症.肠道菌群作为人体内最大的微生态系统,在维持宿主稳态和多种疾病发生发展中占十分重要的地位.近年来,脊髓损伤后肠道菌群的相关研究受到越来越多的关注,使得肠道菌群用于脊髓损伤治疗的临床价值受到越来越多的肯定.肠道菌群不仅与脊髓损伤程度有关,还可以为脊髓损伤后神经源性肠道功能障碍提供治疗靶点.现从肠道菌群在脊髓损伤后迷走神经、下丘脑-垂体-肾上腺轴及代谢产物3个方面探讨其作用机制,分析神经源性肠道功能障碍发生发展与肠道菌群变化的关系,有助于疾病的诊断与治疗.

Cervical spinal cord injury can not only cause serious physical movement and sensory disorders but also lead to serious complications affecting the life safety and quality of life of patients.As the largest microecosystem in the human body,intestinal flora plays a very important role in maintaining host homeostasis and the occurrence and development of many diseases.In recent years,there has been increasing focus on the study of intestinal flora after spinal cord injury,leading to a growing recognition of the clinical value of intestinal flora in the treatment of spinal cord injury.Intestinal flora is not only related to the degree of spinal cord injury but also can provide therapeutic targets for neurogenic intestinal dysfunction after spinal cord injury.This paper discusses the mechanism of intestinal flora in the vagus nerve,hypothalamic-pituitary-adrenal axis,and metabolites after spinal cord injury.It explores the relationship between the occurrence and development of neurogenic intestinal dysfunction and changes in intestinal flora,offering valuable insights for the diagnosis and treatment of related diseases.