绿原酸抗菌作用及机制的研究进展

Advances in research on the antibacterial effects and mechanism of chlorogenic acid

绿原酸是植物体在有氧呼吸过程中经莽草酸途径合成的一种苯丙素类物质,自然存在于多种中药材和食物中,杜仲、金银花和咖啡等植物中含量较高,具有抗菌、抗炎、抗氧化、抗癌和免疫调节等多种药理活性。近年来,绿原酸作为研究活性物质的焦点之一,因其抗菌谱广,对多种细菌和真菌均有较好的抗菌活性,故绿原酸对临床菌株的抗菌作用逐渐被重视和研究。本文综述了近年来国内外关于绿原酸对多种致病菌的抗菌作用及机制的研究进展,旨在为绿原酸抗菌作用的深入研究提供参考,为临床抗感染治疗和控制带来新思路,有助于绿原酸在医药领域的开发。

Chlorogenic acid(CGA)is a phenylpropyl substance synthesized by shikimic acid pathway in plants during aerobic respiration.It naturally exists in a variety of Chinese medicinal materials and foods,with relatively high contents in Eucommia ulmoides,honeysuckle,coffee and other plants,which have various pharmacological activities such as antibacterial,anti-inflammatory,antioxidation,anticancer and immune regulation.In recent years,as one of the focal points of research on active substances,CGA’s antibacterial effect on clinical strains has been gradually paid attention to and studied due to its wide antibacterial spectrum and good antibacterial activity against a variety of bacteria and fungi.This study summarized recent developments in research on the antibacterial action and mechanism of CGA against a variety of pathogenic bacteria both at home and abroad,aiming to provide a reference for further research on the antibacterial activity of CGA,bring new ideas for clinical anti-infection treatment and control,and contribute to the development of CGA in the field of medicine.