矿物类中药治疗失眠的药理作用及临床应用研究进展

Research progress on pharmacological effects and clinical applications of mineral Chinese medicine in the treatment of insomnia

矿物类中药发挥重镇安神作用治疗失眠时疗效显著,通过检索相关著作和文献,发现治疗失眠的矿物药共16种。临床常用于治疗围绝经期失眠、糖尿病相关失眠、抑郁性失眠,顽固性失眠等多种形式引起的慢性失眠。主要通过调节神经递质的异常表达,减少炎性因子、氧化应激因子的释放,下调下丘脑-垂体-肾上腺(HPA)轴激素的分泌,延长慢波和快速动眼睡眠期等发挥治疗作用。现对矿物药的药理研究及临床应用进展作一综述,以期为矿物药在治疗失眠方面的开发与利用提供参考。

Mineral Chinese medicine plays the mind-tranquilizing role in treating insomnia.Through searching relevant works and literature,there are 16 kinds of mineral Chinese medicine for insomnia,which are commonly used in clinical treatment of chronic insomnia caused by various forms such as perimenopausal insomnia,diabetes related insomnia,depressive insomnia,intractable insomnia,etc.They mainly exert therapeutic effects by regulating the abnormal expression of neurotransmitters,reducing the release of inflammatory factors and oxidative stress factors,downregulating the secretion of hypothalamus pituitary adrenal(HPA)axis hormones,prolonging slow wave and rapid eye movement sleep periods.This article reviews the pharmacological research and clinical application progress of mineral Chinese medicine,in order to provide reference for the development and utilization in the treatment of insomnia.