G-CSF、PLGF和PTX3在肺炎患儿血清中的表达及与肺通气功能的关系分析

Analysis of the expression of G-CSF,PLGF,and PTX3 in the serum of children with pneumonia and their relationship with lung ventilation function

目的 探讨粒细胞集落刺激因子(G-CSF)、胎盘生长因子(PLGF)和血清正五聚蛋白3(PTX3)在肺炎患儿血清中的表达及与肺通气功能的关系。方法 本研究以河南大学第一附属医院2021年1月~2023年3月进行治疗的小儿肺炎患者110例作为研究对象,设为观察组,并按照《儿童社区获得性肺炎管理指南(2013修订)》标准,分为轻症组(46例)和重症组(64例)。另选取同期进行健康体检志愿者110例作为对照组,分别对两组的肺活量(FVC)、第一秒用力呼气容积(FEV1)、第一秒用力呼气容积百分比(FEV1%)、G-CSF、PLGF和PTX3进行比较。进一步比较轻症组及重症组患儿之间的FVC、FEV1、FEV1%、G-CSF、PLGF和PTX3差异。采用spearman相关性分析FEV1、FEV1%、FVC与G-CSF、PLGF、PTX3的相关性。结果 观察组患儿的FEV1、FEV1%、FVC均显著低于对照组(P<0.001);重症组患儿的FEV1、FEV1%、FVC均显著低于轻症组(P<0.001);观察组患儿PTX3、G-CSF均显著高于对照组,PLGF低于对照组(P<0.001);重症组患儿PTX3、G-CSF均显著高于轻症组,PLGF低于轻症组(P<0.001);spearman相关性分析显示患儿FEV1、FEV1%、FVC与PTX3、G-CSF呈负相关,与PLGF呈正相关。结论 G-CSF、PLGF和PTX3在肺炎患儿血清中的表达与肺通气功能呈现显著的相关性,可作为病情严重程度判定以及治疗效果分析的重要参考。

Objective To investigate the expression of granulocyte colony-stimulating factor(G-CSF),placental growth factor(PLGF),and serum pentraxin 3(PTX3)in the serum of children with pneumonia and their relationship with lung ventilation function.Methods This study included 110 pediatric patients with pneumonia treated at the First Affiliated Hospital of Henan University from January 2021 to March 2023 as the observation group.They were further divided into a mild group(46 cases)and a severe group(64 cases)according to the"Guidelines for the Management of Community-Acquired Pneumonia in Children(2013 Revision)".Another 110 healthy volunteers who underwent physical examination during the same period were selected as the control group.The forced vital capacity(FVC),forced expiratory volume in one second(FEV1),forced expiratory volume in one second percentage(FEV1%),G-CSF,PLGF,and PTX3 were compared between the two groups.The differences in FVC,FEV1,FEV1%,G-CSF,PLGF,and PTX3 between the mild and severe groups were further compared.Spearman correlation analysis was used to analyze the correlation between FEV1,FEV1%,FVC,and G-CSF,PLGF,PTX3.Results The FEV1,FEV1%,and FVC of the observation group were significantly lower than those of the control group(P<0.001);the FEV1,FEV1%,and FVC of the severe group were significantly lower than those of the mild group(P<0.001);the PTX3 and G-CSF levels in the observation group were significantly higher than those in the control group,while the PLGF level was lower(P<0.001);the PTX3 and G-CSF levels in the severe group were significantly higher than those in the mild group,while the PLGF level was lower(P<0.001);Spearman correlation analysis showed that FEV1,FEV1%,and FVC were negatively correlated with PTX3 and G-CSF,and positively correlated with PLGF.Conclusion The expression of G-CSF,PLGF,and PTX3 in the serum of children with pneumonia shows a significant correlation with lung ventilation function,which can serve as an important reference for assessing the severity of the condition and analyzing treatment effectiveness.