可见光诱导有机光催化合成二氟乙基苯并噁嗪

Visible-Light Induced Organophotocatalysis for the Synthesis of Difluoroethylated Benzoxazines

苯并噁嗪是药物和功能分子中的重要结构.报道了一种利用有机光催化剂在可见光诱导下合成二氟乙基苯并噁嗪的方法.以二氟甲基亚磺酸钠作为二氟甲基化试剂,通过烯烃的氧化二氟甲基化双官能团化反应,可将一系列烯酰胺转化为二氟乙基苯并噁嗪类化合物,该方法操作简单,底物适用广泛.

Benzoxazines are important motif in pharmaceuticals and functional molecules.A visible-light induced photocatalytic strategy for the synthesis of difluoroethyl benzoxazines with organo-photocatalyst was developed.In the present protocol,a series of olefinic amides can be transferred to difluoroethylated benzoxazines via oxydifluoromethylation with CF2HSO2Na as difluoromethylating reagent,which is easily operated and good functional group tolerant.