含双杂原子苯并[d]五元杂环硫醚类化合物的合成研究进展

Research Progress in the Synthesis of Benzo[d]pentamembered Heterocyclic Thioethers Containing Two Heteroatoms

具有双杂原子的苯并[d]噻唑/噁唑/咪唑等苯并[d]五元杂环硫醚结构广泛存在于许多药物分子和天然产物分子中,其衍生物具有抗菌、抗病毒及抗肿瘤等广泛的生物活性,同时也是有机合成的重要中间体及药物合成的结构单元.因此,苯并[d]噻唑/噁唑/咪唑硫醚化合物在医药、材料等领域具有极大的应用价值.其合成方法的研究也成为当前的研究热点之一.综述了近年来具有双杂原子的苯并[d]五元杂环硫醚类化合物的合成方法及其生物活性研究进展,并对其部分反应机理做了相应的阐述.

The thioether structure of benzo[d]penta-membered heterocycles with double heteroatoms,such as benzo[d]thiazole/oxazole/imidazole,widely exists in many drug molecules and natural product molecules.Its derivatives have extensive biological activities such as antibacterial,antiviral and anti-tumor,and are also important intermediates in organic synthesis and structural units in drug synthesis.Therefore,benzo[d]thiazole/oxazole/imidazole sulfide compounds have great application value in medicine,materials and other fields.The research of its synthesis method has also become one of the current research hotspots.The synthesis methods and biological activity research progress of benzo[d]five membered heterocyclic sulfide compounds with double heteroatoms in recent years are reviewed,and some of their reaction mechanisms are described.