经由氮杂邻联烯醌中间体合成轴手性化合物的研究进展

Progress in Synthesis of Axially Chiral Compounds through aza-Vinylidene o-Quinone Methide Intermediates

轴手性化合物不仅是不对称合成领域重要的催化剂和配体,许多天然产物和药物也是轴手性化合物.因此,发展轴手性化合物的高效合成方法是有机化学的重要研究课题.相对已经被广泛研究的邻联烯醌中间体,基于氮杂邻联烯醌中间体的不对称催化反应近年来才受到人们的关注,研究相对较少,有着很大的发展空间.总结了经由氮杂邻联烯醌中间体构建轴手性化合物的研究进展,介绍了反应范围、机理和合成应用.最后对该研究领域的发展前景进行了总结和展望.

Axially chiral compounds are not only important catalysts and ligands in the field of asymmetric synthesis,but also widely exist in many natural products and drugs.Therefore,the development of efficient synthesis of axially chiral compounds has been an important research topic in organic chemistry.Compared with the widely studied vinylidene o-quinone methide(o-VQM)intermediates,the asymmetric catalytic reaction based on the aza-o-VQM intermediates has only attracted people’s attention in recent years,with relatively fewer studies and great potential for development.The progress in the construction of axial chiral compounds through aza-o-VQM intermediates is summarized,and the reaction type,mechanism and synthetic applications are introduced.At last,the prospect of this field is also discussed.