钯催化联烯胺区域选择性芳基酚氧化反应

Palladium-Catalyzed Regioselective Aryl Phenoxylation of Allenamide

在温和的反应条件下,实现了一种钯催化的联烯胺与苯酚衍生物的区域选择性芳基酚氧化反应,以中等至优异的产率提供了有价值的支链烯丙基醚产物.该反应过程中只观察到了联烯胺的近端加成产物,没有观察到远端加成产物.这种在联烯胺的α位置发生的亲核进攻可能是由钯配合物的位阻效应引起的.

A palladium-catalyzed regioselective aryl phenoxylation of allenamide with phenol derivatives has been developed,providing valuable branched allyl ether products in moderate to excellent yields under mild reaction conditions.Importantly,only the proximal addition products of allenamide were observed in the reaction process,and no distal addition products were observed.A coordinated palladium complex was proposed to be responsible for the excellent proximal addition in the insertion step.The final nucleophilic attack atα-position was induced by the steric effect of palladium complex.