磷酸铝凝胶联合奥美拉唑三联疗法在小儿消化性溃疡临床治疗中的应用价值

Value of Aluminum Phosphate Gel Combined with Omeprazole Triple Therapy in the Clinical Treatment of Pediatric Peptic Ulcer

目的:探究磷酸铝凝胶联合奥美拉唑三联疗法在小儿消化性溃疡临床治疗中的应用价值。方法:选取2021年1月—2022年6月洛阳市妇幼保健院收治的86例小儿消化性溃疡患儿作为研究对象。以随机数表法将其分为研究组和常规组,每组各43例,常规组患儿予以奥美拉唑三联疗法治疗,研究组患儿予以磷酸铝凝胶联合奥美拉唑三联疗法治疗。比较两组患儿治疗4周后的临床疗效、胃泌素(GAS)、血清降钙素原(PCT)以及不良反应发生情况。结果:两组患儿的临床疗效比较,差异有统计学意义(χ^(2)=5.460,P<0.05);治疗后,两组患儿血清PCT、GAS水平低于治疗前,研究组患儿血清PCT、GAS水平均低于常规组患儿,差异有统计学意义(t=4.031、10.296,P<0.05),两组患儿均未出现严重不良反应,研究组患儿头晕、恶心各1例,常规组头晕、恶心各2例,两组患儿不良反应发生率比较,差异无统计学意义(χ^(2)=0.717,P>0.05)。结论:在小儿消化性溃疡临床治疗中,通过采用磷酸铝凝胶联合奥美拉唑三联疗法,可有效改善治疗效果,降低血清PCT、GAS水平,且安全性良好。

Objective:To investigate the value of aluminum phosphate gel combined with omeprazole triple therapy in the clinical treatment of pediatric peptic ulcer.Methods:86 cases of pediatric peptic ulcer children admitted to the hospital from January 2021 to June 2022 were selected as the study subjects,and they were divided into the study group and the conventional group by random number table method,with 43 cases in each group.Children in the conventional group were treated with omeprazole triple therapy,and children in the study group were treated with aluminum phosphate gel combined with omeprazole triple therapy.The clinical efficacy,gastrin(GAS),serum procalcitonin(PCT)and the occurrence of adverse reactions were compared between the two groups after 4 weeks of treatment.Results:The difference in clinical efficacy between the two groups of children is statistically significant(χ^(2)=5.460,P<0.05).After treatment,the serum PCT and GAS levels of the children in the two groups were lower than those before treatment,and the serum PCT and GAS levels of the children in the study group were lower than those in the conventional group,and the difference was statistically significant(t=4.031,10.296;P<0.05).No serious adverse reactions occurred in the two groups of children,one case each of dizziness and nausea in the study group and two cases each of dizziness and nausea in the conventional group.The difference in the incidence of adverse reactions between the two groups was not statistically significant(χ^(2)=0.717,P>0.05).Conclusion:In the clinical treatment of pediatric peptic ulcer,by using aluminum phosphate gel combined with omeprazole triple therapy,it can effectively improve the therapeutic efficacy,reduce serum PCT and GAS levels,and has good safety.