黄连素在血液肿瘤中的作用及相关机制研究进展

Research Progress on the Role of Berberine in Hematologic Malignancies and Its Related Mechanisms--Review

传统中药黄连素是一种从黄连根茎中提取的异喹啉类生物碱,具有抗炎、止泻等作用,既往较常用于治疗感染和胃肠道疾病。近年来研究发现,黄连素可在白血病、淋巴瘤、多发性骨髓瘤等肿瘤治疗中发挥广泛的抗癌效应。在血液系统恶性肿瘤中,黄连素可诱导细胞自噬、促进细胞凋亡、调节细胞周期、抑制炎症反应、造成癌细胞氧化损伤,并可与miRNA相互作用,从而抑制癌细胞的增殖、迁移以及集落形成。本文就黄连素在恶性血液病中的作用及相关机制进行综述。

Berberine,a traditional Chinese medicine,is an isoquinoline alkaloid extracted from the rhizome of Coptis chinensis.It has anti-inflammatory and antidiarrheal effects and is commonly used in the treatment of infections and gastrointestinal diseases.In recent years,studies have found that berberine can play a wide range of anti-cancer effects in the treatment of leukemia,lymphoma,multiple myeloma,etc.In hematologic malignancies,berberine can induce autophagy,promote apoptosis,regulate cell cycle,inhibit inflammatory response,cause oxidative damage to cancer cells and interact with miRNA to inhibit the proliferation,migration and colony formation of cancer cells.This paper will review the role and related mechanisms of berberine in hematological malignancies.