慢性移植物抗宿主病的发病机制和治疗前景

Pathogenesis and Therapeutic Prospects of Chronic Graft-Versus-Host Disease--Review

慢性移植物抗宿主病是异基因造血干细胞移植(allo-HSCT)后影响患者长期生存及生活质量的主要并发症之一,发生率可达30%-70%。与急性移植物抗宿主病不同,慢性移植物抗宿主病除了由供体异常激活的T细胞和具有供体淋巴细胞浸润和宿主靶器官损害特征的细胞因子风暴外还涉及许多的免疫细胞和细胞因子。近期研究围绕相关免疫细胞和细胞因子为靶点也取得了一定进展。本文将从经典固有免疫和适应性免疫角度论述慢性移植物抗宿主病的发病机制及治疗前景。

Chronic graft-versus-host disease(cGVHD)is one of a major complication that affecting the long-term survival and living quality of patients after allogeneic hematopoietic stem cell transplantation,with the incidence of 30%-70%.Unlike acute GVHD,cGVHD involves a large number of immune cells and cytokines in addition to T cell,which is activated abnormally by the donor,and cytokine storms,which characterized by infiltration of donor lymphocytes and damage to host target organ.Recent studies have further made progress in targeting related immune cells and cytokines.In this review,the pathogenesis and therapeutic prospects of cGVHD were summarized from the perspectives of classical innate and adaptive immunity.