PE患者血清NfL、IFI16、TGF-β1水平变化及其预测妊娠结局价值

Changes of the levels of neurofilament light Chain Protein,human gamma interferon inducible protein 16 and transforming growth factor β1 of pregnant women with preeclampsia and their predictive value for the pregnancy outcomes

目的:探讨子痫前期(PE)患者血清神经丝轻链蛋白(NfL)、人γ干扰素诱导蛋白16(IFI16)、转化生长因子β1(TGF-β1)水平变化及其对不良妊娠结局的预测价值。方法:选择2021年1月-2023年1月本院接诊的PE患者97例临床资料为病例组,根据围产结局分为正常组32例,母体不良结局组27例,围生儿不良结局组38例;同期产前检查健康孕妇95例为对照组,分析各组血清NfL、IFI16、TGF-β1水平及其对PE患者妊娠结局的预测价值。结果:病例组血清NfL(4.89±0.56 pg/ml)、IFI16(17.84±2.14 ng/ml)、TGF-β1(84.21±9.41 pg/ml)水平高于对照组(4.41±0.16 pg/ml、13.35±1.28 ng/ml、68.71±5.98 pg/ml),妊娠结局正常患者、母体不良结局患者、围生儿不良结局患者血清中依次升高(均P<0.05);受试者工作特征曲线分析,预测PE患者不良妊娠结局,血清NfL的曲线下面积(AUC)为0.807,灵敏度82.7%,特异度85.0%,截断值4.64pg/ml;血清IFI16的AUC为0.973,灵敏度86.9%,特异度90.0%,截断值15.69 ng/ml;血清TGF-β1的AUC为0.921,灵敏度93.5%,特异度98.5%,截断值74.56 pg/ml。结论:PE患者血清NfL、IFI16、TGF-β1表达异常升高,且与不良妊娠结局有关,可作为评估妊娠结局的有效指标。

Objective:To study the changes of the levels of neurofilament light Chain Protein(NfL),human gamma interferon inducible protein 16(IFI16)and transforming growth factorβ1 of paregnant women with preeclampsia(PE),and to study their predictive value for the pregnancy outcomes of the women.Methods:97 pregnant women with PE were selected in study group and were divided into group A(32 cases with normal pregnancy outcomes),group B(27 cases with adverse maternal outcomes),and group C(38 cases with the adverse perinatal outcomes)according to the perinatal outcomes from January 2021 to January 2023.95 healthy pregnant women were selected in control group during the same period.The levels of the serum NfL,IFI16 and TGF-β1 levels of the women in these groups and their predictive values for the pregnancy outcomes of the women were analyzed.Results:The levels of the serum NfL(4.89±0.56 pg/ml),IFI16(17.84±2.14 ng/ml)and TGF-β1(84.21±9.41 pg/ml)of the women in the study group were significantly higher than those(4.41±0.16 pg/ml,13.35±1.28)ng/ml and 68.71±5.98 pg/ml)of the women in the control group.The levels of serum NfL,IFI16 and TGF-β1 of the women in group A,in group B and in group C had increased gradually(all P<0.05).Receiver operating characteristic curve analysis showed that the area under the curve(AUC)of the serum NfL level of the women with PE for predicting their adverse pregnancy outcomes was 0.807,the sensitivity of which was 82.7%,the specificity of which was 85.0%,and the cut-off value of which was 4.64pg/ml.The AUC of the serum IFI16 level of the women with PE for predicting their adverse pregnancy outcomes was 0.973,the sensitivity of which was 86.9%,the specificity of which was 90.0%,and the cut-off value of which was 15.69ng/ml.The AUC of the serum TGF-β1 level of the women with PE for predicting their adverse pregnancy outcomes was 0.921,the sensitivity of which was 93.5%,the specificity of which was 98.5%,and the cut-off value of which was74.56pg/ml.Conclusion:The levels of the serum NfL,IFI16 and TGF-β1 of the pregnant women with PE are abnormal and are closely related to the adverse pregnancy outcomes of the women,and which can be used as the indicators to evaluate the pregnancy outcomes of the women effectively.