卵巢颗粒细胞瘤8例临床病理观察并文献复习

Clinicopathological observation of 8 patients with ovarian granulosa cell tumor and the literature review

目的:探讨卵巢颗粒细胞瘤的临床病理特征、诊断、鉴别诊断及预后。方法:收集本院2013-2023年诊断为卵巢颗粒细胞瘤的病例8例。分析其临床病理学特征及免疫组化表型,并复习相关文献。结果:8例平均年龄54岁,均手术治疗,除1例8年后复发死亡外,其余均存活。肿瘤平均大小10.38cm,呈囊性、多房囊性或实性。镜下肿瘤呈弥漫、实性排列,也可见假乳头状、岛状、巢团状、被富于细胞的纤维间质分隔。免疫组化显示肿瘤细胞α-Inhibin、Vimentin、CD99阳性,EMA、CK7阴性。结论:卵巢颗粒细胞瘤是低度恶性肿瘤,镜下表现方式多样,免疫组化染色及基因检测可协助诊断。手术治疗是主要方式,存在远期复发可能,需要定期随诊。

Objective:To investigate the clinicopathological features,diagnosis,differential diagnosis and prognosis of the ovarian granulosa cell tumor of patients.Methods:8 patients with ovarian granulosa cell tumor diagnosed in hospital from 2013 to 2021 were collected.The clinicopathological characteristics and immunohistochemical phenotype of these patients were analyzed.And the literatures about ovarian granulosa cell tumor were reviewed.Results:The mean age of the patients with ovarian granulosa cell tumor was 54 years old.All the patients had undergone surgical treatment and had survived except 1 patient who died because of the recurrence of the ovarian granulosa cell tumor in the 8th year after surgery.The mean size of the tumors of the patients was 10.38 cm,and the tumors had showed the cystic,multilocular cystic or solid.Microscopically,the tumors cells were arranged in a diffuse and solid pattern,and some tumors cells had showed the pseudopapillary,island,or nested pattern,and were separated by the fibrous stroma with rich cells.Immunohistochemical analysis showed that the tumor cells were positive forα-Inhibin,Vimentin and CD99,but were negative for EMA and CK7.Conclusion:Granulosa cell tumor of the ovary is a low-grade tumor with various manifestations under the microscope.Immunohistochemical staining and gene detection can assist in the diagnosis of the granulosa cell tumor of the ovary.Surgical treatment is the main method for the tumor,which may have the long-term recurrence,so the regular follow-up of the patients is required.