合并代谢功能障碍的慢性HBV感染者的临床管理

Clinical management of chronic hepatitis B virus infection comorbid with metabolic dysfunction

随着代谢功能障碍相关疾病在全球范围内快速增长,慢性HBV感染合并代谢功能障碍的患者也逐年增加。高血糖、高血压和血脂异常等代谢功能障碍的合并存在可能会使慢性HBV感染者发生不良肝脏结局和心血管事件的风险增加,并影响抗HBV治疗的应答反应。合并代谢功能障碍的慢性HBV感染者的规范管理成为当前面临的一个挑战。进一步研究代谢功能障碍与HBV之间的相互作用以及针对性的管理策略,将有助于优化慢性HBV感染者的临床管理。

With the rapid growth of metabolic dysfunction(MD)worldwide,there is also a gradual increase in the number of patients with chronic hepatitis B virus(HBV)infection and MD.Comorbidity with metabolic disorders such as hyperglycemia,hypertension,and dyslipidemia may increase the risk of adverse liver outcomes and cardiovascular events in patients with chronic HBV infection and affect the response to anti-HBV therapy.The standardized management of patients with chronic HBV infection and MD has become a challenge at present,and further in-depth research on the interaction between MD and HBV and targeted management strategies will help to optimize the clinical management of patients with chronic HBV infection.