阿瑞匹坦乳液氢键作用近红外光谱研究

Near infrared spectroscopic study on hydrogen bonding of arepidtan lotion

为了研究阿瑞匹坦乳液的稳定性开展了阿瑞匹坦乳液氢键作用研究。分别研究不同浓度阿瑞匹坦乳液(包括:供试品溶液1、供试品溶液2、供试品溶液3、供试品溶液4和供试品溶液5)的近红外(NIR)光谱。结果表明,阿瑞匹坦乳液近红外光谱红外吸收模式主要包括:ν_(阿瑞匹坦乳液)-1-NIR(9000~6000 cm^(-1))和ν_(阿瑞匹坦乳液)-2-NIR(6000~4000 cm^(-1)),氯化钠会破坏水分子间的氢键作用(供试品溶液1和供试品溶液2),而阿瑞匹坦乳液会进一步加强水分子间的氢键作用(供试品溶液3、供试品溶液4和供试品溶液5),而之间也存在着一个巧妙的平衡。

In order to study the hydrogen bonding of aprepitant emulsion for studying the stability of aprepitant emulsion.The near-infrared(NIR)spectra of arepidtan lotion with different concentrations(including test solution 1,test solution 2,test solution 3,test solution 4 and test solution 5)were studied respectively.The results show that the near-infrared absorption modes of Arepidtan lotion mainly include:ν_(Arepidtan lotion)-1-NIR(9000~6000 cm^(-1))and ν_(Arepidtan lotion)-2-NIR(6000~4000 cm^(-1)),Sodium chloride will break the hydrogen bond between water molecules(test solution and test solution 2),while arepidtan lotion will further strengthen the hydrogen bond between water molecules(test solution 3,test solution 4 and test solution 5),and there is also a clever balance between them.