血小板相关参数在儿童慢性自发性荨麻疹中的临床价值探讨

The clinical significance of platelet-related parameters in childhood chronic spontaneous urticaria

目的探究血小板相关参数在慢性自发性荨麻疹(CSU)患儿中的临床意义。方法纳入68例儿童CSU患者作为观察组,68例体检健康儿童作为对照组,比较两组血小板计数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)等血小板相关参数有无差异,并分析观察组的疾病病程、病情严重程度与血小板相关参数的相关性。结果观察组PLT水平显著高于对照组(t=3.96,P<0.001),而MPV(t=-5.99,P<0.001)、PDW(t=-8.12,P<0.001)水平显著低于对照组。不同病情严重程度患者间PLT、MPV、PDW水平均无统计学差异(均P>0.05)。CSU患者中MPV(r=0.26,P=0.034)、PDW(r=0.35,P=0.004)水平与病程呈正相关,与PLT水平(MPV:r=-0.41,P<0.05;PDW:r=-0.34,P=0.002)呈负相关,而PLT水平与病程无相关性(r=0.02,P=0.875)。结论血小板相关参数可反映儿童CSU的发生发展。MPV和PDW可以作为评估血小板活化的指标,也可作为推测CSU患儿病程的潜在指标。

Objective To explore the clinical significance of platelet-related parameters in children with chronic spontaneous urticaria(CSU).Methods Sixty-eight children with CSU and 68 children without CSU were enrolled.The differences in platelet-related parameters,including platelet count(PLT),mean platelet volume(MPV),and platelet distribution width(PDW),were compared between the two groups.The association of the disease course and disease severity with platelet-related parameters were analyzed in CSU children.Results PLT levels were significantly higher in children with CSU than in that without CSU(t=3.96,P<0.001).In contrast,children with CSU had significantly lower MPV(t=-5.99,P<0.001)and PDW(t=-8.12,P<0.001)than children without CSU.Moreover,severity of disease did not correlated with PLT,MPV and PDW(P>0.05).However,the disease course correlated positively with MPV(r=0.26,P=0.034)and PDW(r=0.35,P=0.004),but not with PLT levels(r=0.02,P=0.875),in children with CSU.PLT levels negatively correlated with MPV(r=-0.41,P<0.05)and PDW(r=-0.34,P<0.05).Conclusions Platelet-related parameters can reflect the occurrence and development of CSU in children.MPV and PDW can serve as indicators to evaluate platelet activation and predictors of the course of CSU in children.