来源于植物提取物的群体感应抑制剂抑制痤疮致病菌机制的研究进展

Research progress on the mechanisms by which plant-originated quorum sensing inhibitors inhibit pathogenic bacteria of acne

痤疮致病菌主要有痤疮丙酸杆菌、金黄色葡萄球菌、表皮葡萄球菌。群体感应与细菌毒力因子的表达及生物膜的形成密切相关,是细菌存活的重要因素。目前已确定金黄色葡萄球菌及表皮葡萄球菌的群体感应系统的类型,但痤疮丙酸杆菌的群体感应类型尚存在争议。副作用小的植物提取物类的群体感应抑制剂在痤疮的治疗中具备较大潜能。本文主要对来源于植物提取物的群体感应抑制剂在抑制痤疮致病菌中的机制研究进展进行综述。

The main acne-causing bacteria are Propionibacterium acnes,Staphylococcus aureus and Staphylococcus epidermidis.Quorum sensing,an important factor for bacterial survival,is closely associated with expression of bacterial virulence factors and biofilm formation.Although the quorum sensing types of Staphylococcus aureus and Staphylococcus epidermidis have been identified,the quorum sensing types of Propionibacterium acnes are still controversial.Plant-orginated quorum sensing inhibitors with few side effects have a greater potential in the treatment of acne.This article reviews the progress on the mechanisms by which plant-originated quorum sensing inhibitors inhibit pathogenic bacteria of acne.