蓝光治疗毯联合肠道益生菌治疗新生儿高胆红素血症的临床疗效

Clinical efficacy of blue light therapeutic blanket combined with intestinal probiotics in treating neonatal hyperbilirubinemia

目的观察蓝光治疗毯联合肠道益生菌治疗新生儿高胆红素血症的临床疗效。方法92例新生儿高胆红素血症患儿随机分为两组,每组46例。对照组单用肠道益生菌口服,观察组加用蓝光治疗毯间歇光疗,治疗3d。检测治疗前和光疗结束后12h经皮胆红素水平,比较两组患儿治疗前后的经皮胆红素水平变化以及治疗有效率。结果观察组治疗有效率高于对照组(82.61%vs.60.87%)(P<0.05)。治疗前,两组患儿的经皮胆红素水平差异无统计学意义(P>0.05);治疗后,观察组经皮胆红素水平低于对照组[(200.03±18.85)μmol/L vs.(209.97±22.00)μmol/L)](P<0.05)。结论在口服肠道益生菌治疗基础上,加用蓝光治疗毯间歇光疗可以进一步改善高胆红素血症新生儿的症状。

Objective To observe the clinical efficacy of blue light therapeutic blanket combined with intestinal probiotics in the treatment of neonatal hyperbilirubinemia.Methods A total of 92 neonates with neonatal hyperbilirubinemia were randomly divided into two groups with 46cases each.The neonates in group C were treated with conventional oral intestinal probiotics alone and those in group A were treated additionally with intermittent phototherapy of blue light therapeutic blanket for 3days.The transcutaneous bilirubin levels were detected before treatment and at 12hours after phototherapy.The therapeutic effectiveness rate and the changes of fetal transcutaneous bilirubin level were compared between the two groups.Results The therapeutic effectiveness rate was higher in group A than that in group C(82.61%vs.60.87%)(P<0.05).There was no significant difference in the transcutaneous bilirubin level before treatment(P>0.05),which after treatment was lower in group A than that in group C[(200.03±18.85)μmol/L vs.(209.97±22.00)μmol/L](P<0.05).Conclusion On the basis of oral intestinal probiotics,adding intermittent phototherapy of blue light therapeutic blanket can more effectively improve the symptoms of the neonates with hyperbilirubinemia.