摘要
内部核糖体进入位点(Internal ribosome entry site,IRES)是一种存在于RNA内部的特殊功能元件,其可在不依赖5’端帽子结构的情况下直接招募核糖体启动蛋白翻译,已被发现与多种细胞过程密切相关。近来,越来越多的证据表明IRES在环形RNA翻译调控中扮演着极其重要的角色,由此IRES引起人们的极大关注。本文针对目前真核细胞中IRES介导的翻译调控机制进行了综述,并对IRES元件相关生物信息学工具进行了总结。
Internal ribosome entry site(IRES)is a special functional element in RNA,which can directly recruit ribosome to initiate protein translation independently of the 5’end cap structure.It has been found to be closely related to a variety of cell processes.Recently,IRES have attracted a lot of attention due to increasing evidence that they play an extremely important role in the regulation of circular RNA translation.This paper reviews the current mechanism of IRES-mediated translation regulation in eukaryotic cells,and summarizes the bioinformatics tools related to IRES elements.
作者
轩依然
赵健
宋晓峰
XUAN Yiran;ZHAO Jian;SONG Xiaofeng(College of Automation Engineering,Nanjing University of Aeronautics and Astronautics,Nanjing 211106,China)
出处
《生物信息学》
2024年第1期1-10,共10页
Chinese Journal of Bioinformatics
基金
国家自然科学基金项目(No.62003165,62273175,61973155)
江苏省重点研发计划项目(No.BE2022843)
中国博士后科学基金项目(No.2019M661817).