IRES介导的非帽依赖翻译调控研究进展

Review on IRES-mediated cap-independent translation regulation

内部核糖体进入位点(Internal ribosome entry site,IRES)是一种存在于RNA内部的特殊功能元件,其可在不依赖5’端帽子结构的情况下直接招募核糖体启动蛋白翻译,已被发现与多种细胞过程密切相关。近来,越来越多的证据表明IRES在环形RNA翻译调控中扮演着极其重要的角色,由此IRES引起人们的极大关注。本文针对目前真核细胞中IRES介导的翻译调控机制进行了综述,并对IRES元件相关生物信息学工具进行了总结。

Internal ribosome entry site(IRES)is a special functional element in RNA,which can directly recruit ribosome to initiate protein translation independently of the 5’end cap structure.It has been found to be closely related to a variety of cell processes.Recently,IRES have attracted a lot of attention due to increasing evidence that they play an extremely important role in the regulation of circular RNA translation.This paper reviews the current mechanism of IRES-mediated translation regulation in eukaryotic cells,and summarizes the bioinformatics tools related to IRES elements.