高血压与肾透明细胞癌的相关性研究

Correlation between hypertension and clear cell renal cell carcinoma

目的:探讨高血压与肾透明细胞癌(ccRCC)的相关性。方法:选择经病理证实的ccRCC患者164例,其中高血压病程≥3年者定为高血压组(57例),从未诊断高血压者定为非高血压组(107例),另收集58例健康志愿者作为对照组。测量并计算肿瘤、对侧健康肾脏和对照组肾脏的ADC值及相对ADC(rADC),利用SPSS24.0软件分析相关数据。结果:高血压组肿瘤ADC值为(1.683±0.435)×10^(-3) mm^(2)/s,对侧健康肾脏ADC值为2.047(0.373)×10^(-3) mm^(2)/s,rADC值为0.83±0.20;非高血压组肿瘤ADC值为(1.863±0.401)×10^(-3) mm^(2)/s,对侧健康肾脏ADC值为2.011(0.290)×10^(-3) mm^(2)/s,rADC值为0.95±0.20。高血压组与非高血压组肿瘤ADC值差异有统计学意义(P=0.009),2组对侧健康肾脏ADC值差异无统计学意义(P=0.136),2组rADC值差异有统计学意义(P=0.001)。结论:高血压与ccRCC的ADC值降低有相关性,其可能使得肿瘤的恶性程度增加。

Objective:To investigate the correlation between hypertension and clear cell renal cell carcinoma(ccRCC).Methods:The data from 164 ccRCC patients and 58 healthy controls were collected.The ccRCC patients with a history of hypertension of 3 years or more composed the hypertension group(57 cases),and the ccRCC patients who had never been diagnosed with hypertension composed the non-hypertension group(107 cases).The ADC and rADC values of tumor,the contralateral healthy kidney and the control group were measured and calculated,and relevant data were analyzed by SPSS 24.0 software.Results:In the hypertension group,the ADC values of the tumors and the contralateral healthy kidney were(1.683±0.435)×10^(-3) and 2.047(0.373)×10^(-3) mm^(2)/s,respectively,and the rADC value was 0.83±0.20.In the non-hypertension group,the ADC values of the tumors and the contralateral healthy kidney were(1.863±0.401)×10^(-3) and 2.011(0.290)×10^(-3) mm²/s,respectively,and the rADC value was 0.95±0.20.The ADC value of the tumors was significantly different between the hypertension group and the non-hypertension group(P=0.009),and the ADC value of the contralateral kidney wasn’t significantly(P=0.136),the rADC value was significantly different(P=0.001).Conclusion:Hypertension is associated with a decrease in ADC value of ccRCC,which may increase tumor malignancy.