摘要
Tau protein is encoded by the microtubuleassociated protein tau(MAPT)gene and stabilizes microtubules in the neurons.Tau has unique biophysical properties that make it both highly water-soluble and positively charged.Although tau is an intrinsically disordered protein lacking defined secondary structures,it can acquire highly organized-sheet structures and stack into a filamentous inclusion such as a paired helical filament(PHF).
基金
supported by grants from the National Research Foundation of Korea (2021 R1A2C2008023,2020R1A5A 1019023
RS-2023-00261784 to MJL
2021R1/1A1A 01051245to JHL)。