let-7i-5p在肿瘤中的研究进展

Research Progress on Role of let-7i-5p in Tumor

let-7i-5p是非编码小分子RNA(miRNA)中的一员,它通过多靶点和信号通路来抑制肿瘤的生长、增殖和迁移,还具有调节肿瘤微环境延缓癌症进展和改善肿瘤耐药的作用。文章综述了let-7i-5p在肝癌、乳腺癌、结直肠癌、宫颈癌、鼻咽癌、肾癌和胶质母细胞瘤中的研究进展。有望发掘let-7i-5p成为新肿瘤标志物,为肿瘤的防治提供新策略。

let-7i-5p is a member of non-coding small molecule RNA(miRNA),which inhibits tumor growth,proliferation and migration through multiple targets and signaling pathways.It also has the effect of regulating tumor microenvironment to delay cancer progression and improve tumor drug resistance.This article reviews the research progress of the mechanism of let-7i-5p in liver cancer,breast cancer,colon cancer,cervical cancer,nasopharyngeal cancer,kidney cancer and glioblastoma.It is expected to explore the role that let-7i-5p can play as a new tumor marker to provide a new strategy for tumor prevention and treatment.