糖皮质激素诱导小梁网组织失能的研究进展

Research Progress on Glucocorticoids Induced Dysfunction of Trabecular Meshwork

糖皮质激素(glucocorticoids,GCs)作用于小梁网组织,诱导发生组织形态学的改变与功能失衡。研究证实糖皮质激素性青光眼与原发性开角型青光眼(primary open angle glaucoma,POAG)具有相似的小梁网形态与功能变化,然而POAG的发病机制仍不清楚。阐明GCs如何诱导小梁网形态学的改变,如何影响房水流出阻力,有利于探索POAG的发病机制。文章主要就GCs对小梁网的影响作一综述。

Glucocorticoids(GCs)could induce the morphological changes and dysfunction of trabecular meshwork tissues.The changes in the trabecular meshwork tissues of the glucocorticoids(GCs)induced glaucoma is similar with those of the primary open angle glaucoma(POAG).However,the pathogenesis of POAG is still unclear,elucidating how GCs induce morphological changes of trabecular meshwork and the increase of aqueous humor outflow resistance is beneficial for exploring the pathogenesis of POAG.The effects of GCs on trabecular meshwork are summarized in this review.