摘要
DearEditor,Eukaryotic transcription by RNA polymerase I(Pol I)is a strictly regulated process that involves the interplay of numerous factors.Promoter-proximal pausing is a regulatory mechanism that connects transcription initiation and productive elongation in metazoans(Core and Adelman,2019).Pol II forms a paused elongation complex(PEC)through binding of two transcriptional regulation factors DSIF and NELF(Vos et al.,2018).Following the duration of pausing,Pol II either proceeds into productive elongation or undergoes promoter-proximal premature transcription termination(PTT)(Kamieniarz-Gdula and Proudfoot,2019),which plays a decisive role in determining transcriptional outputs.
基金
supported by grants from the National key R&D program of China(No.2021YFA1300100)
the National Natural Science Foundation of China(Nos.32271308,32030055,31830107,and 31821002)
the XPLORER Prize(YX.),the Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX01)
Shanghai Municipal Science and Technology Commission(No.19JC1411500)
the Science and Technology Major Project of Inner Mongolia Autonomous Region of China to the State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock(No.2020ZD0008).
